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PROTAC sEH-degrader-3

sEH PROTAC Degrader

PROTAC sEH-degrader-3 is a selective sEH PROTAC degrader that specifically targets soluble epoxide hydrolase (sEH) in the cytosol, sparing its activity in peroxisomes. This compound induces degradation of sEH via a CRBN-mediated lysosomal pathway, exhibiting an IC50 of 0.8 nM against human sEH. PROTAC sEH-degrader-3 is valuable for research focusing on endoplasmic reticulum stress, inflammation, and metabolic diseases, offering insights into therapeutic strategies targeting these pathways.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Degrader
CAS Number	3093413-94-3
Applications	sEH PROTAC Degrader
Formula	C₄₆H₅₃F₃N₆O₁₄
Molecular Weight	970.94
SMILES	O=C(COC1=C(C2=O)C(C(N2C3CCC(NC3=O)=O)=O)=CC=C1)NCCOCCOCCOCCOCCNC(C4=CC=C(O[C@@H]5CC[C@H](CC5)NC(NC6=CC=C(OC(F)(F)F)C=C6)=O)C=C4)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.