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PROTAC SMARCA2/4-degrader-11

PROTAC degrader

PROTAC SMARCA2/4-degrader-11 is a targeted protein degradation tool that specifically promotes the degradation of the SMARCA family of proteins. With a DC50 value of less than 100 nM, this compound effectively induces the destruction of SMARCA2 and SMARCA4. Its unique design features an inhibitor component, a linker, and an E3 ligase ligand, facilitating the targeted removal of these proteins, making it a valuable reagent for research into cancer biology and epigenetic regulation.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Degrader
CAS Number	2568276-71-9
Applications	PROTAC degrader
Formula	C₃₇H₄₁N₉O₄
Molecular Weight	675.78
SMILES	CN1C(N(C2=C1C(C3CCC(CC3)N4CCC(CC4)N5C=C(C=N5)C6=CC(C7=CC=CC=C7O)=NN=C6N)=CC=C2)C8CCC(NC8=O)=O)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.