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PROTAC SMARCA2 degrader-1

BRM2 Degrader

PROTAC SMARCA2 degrader-1 is a targeted degrader designed to selectively degrade BRM2 (SMARCA2) with a DC50 value of less than 0.1 μM. This compound functions as an E3 ubiquitin ligase binding linker, facilitating the targeted degradation of specific proteins. Its application in cancer research makes it a valuable tool for elucidating the role of BRM2 in tumor biology and developing potential therapeutic strategies.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Degrader
CAS Number	2892523-73-6
Applications	BRM2 Degrader
Formula	C₄₉H₆₂N₁₀O₆S
Molecular Weight	919.14
SMILES	OC(C=CC=C1)=C1C2=NN=C(NC3)C(NC3(CCC4)CN4CC5CCN(CC5)CCOC6=NOC([C@@H](C(C)C)C(N7[C@@H](C[C@H](C7)O)C(N[C@H](C8=CC=C(C9=C(C)N=CS9)C=C8)C)=O)=O)=C6)=C2

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.