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PROTAC SOS1 degrader-6

PROTAC SOS1 Degrader

PROTAC SOS1 degrader-6 is a targeted degradative compound designed to selectively degrade the SOS1 protein through a PROTAC mechanism. By utilizing a ligand for SOS1, an E3 ubiquitin ligase ligand, and an effective linker, this reagent enhances the efficacy of KRASG12C inhibitors. Its application is primarily in the study of KRAS-driven cancers and the exploration of protein homeostasis through targeted protein degradation pathways.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Degrader
CAS Number	3032282-51-9
Applications	PROTAC SOS1 Degrader
Formula	C₄₆H₅₅F₃N₈O₆S
Molecular Weight	905.04
SMILES	CC1=NC2=C(C=C(C(OC)=C2)OCCCCC(N[C@@H](C(C)(C)C)C(N3C[C@H](O)C[C@H]3C(NCC4=CC=C(C5=C(C)N=CS5)C=C4)=O)=O)=O)C(N[C@H](C)C6=CC(N)=CC(C(F)(F)F)=C6)=N1

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.