Fig. 1 · Structure
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PROTAC TYK2 degrader-1
TYK2 Degrader
PROTAC TYK2 degrader-1 (CPD-155) is a proteolysis-targeting chimera (PROTAC) that effectively degrades TYK2, achieving a degradation efficiency (Dmax) exceeding 60%. This compound utilizes a selective TYK2 ligand combined with a Cereblon ligand, linked through a proprietary structure. It is poised for applications in research focusing on autoimmune diseases and inflammatory disorders where TYK2 modulation is of interest.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Degrader |
| CAS Number | 2770470-20-5 |
| Applications | TYK2 Degrader |
| Formula | C40H41N13O7 |
| Molecular Weight | 815.84 |
| SMILES | CNC(C1=NN=C(C=C1NC2=CC=CC(C3=NN(C=N3)C)=C2OC)NC4=NC=C(C=C4)C(NCCCCCNC5=CC=CC6=C5C(N(C6=O)C7CCC(NC7=O)=O)=O)=O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.