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Protease-Activated Receptor-1 antagonist 2

PAR-1 Antagonist

Protease-Activated Receptor-1 Antagonist 2 is a potent oral antagonist of the protease-activated receptor-1 (PAR-1), exhibiting an IC50 value of 7 nM. This compound demonstrates favorable pharmacokinetic properties, making it an essential tool for studying cardiovascular diseases, including atherosclerosis and restenosis. Its targeted action on PAR-1 allows for in-depth exploration of its role in vascular biology and potential therapeutic interventions.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Antagonist
CAS Number	1454588-34-1
Applications	PAR-1 Antagonist
Formula	C₂₄H₂₃F₂N₃O₂
Molecular Weight	423.46
SMILES	[H][C@]12[C@H]([C@@H](C(F)(C[C@]1(C(O[C@@H]2C)=O)N)F)C)/C=C/C3=CC=C(C=N3)C4=CC=CC=C4C#N

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.