Protein kinase inhibitor 1

Catalog No.: A35074
DYRK Inhibitor
Protein Kinase Inhibitor 1 is a selective inhibitor of dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A), demonstrating an IC50 of 74 nM and a Kd of 9.5 nM. This compound is instrumental in the investigation of DYRK1A's role in various cellular processes, including neurodevelopment and cancer progression. It serves as a valuable tool for research applications focused on kinase signaling pathways and their implications in disease states.
Grouped product items
Size Price Stock Qty
5mg
$65.00
In stock
10mg
$120.00
In stock
25mg
$260.00
In stock
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Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
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Cell Vol 177, Issue 7, p1933-1947.e25
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Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
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Nature volume 574, pages268-272 (2019)
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Nature volume 551, pages639-643 (2017)
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Biological Activity
DescriptionProtein Kinase Inhibitor 1 is a selective inhibitor of dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A), demonstrating an IC50 of 74 nM and a Kd of 9.5 nM. This compound is instrumental in the investigation of DYRK1A's role in various cellular processes, including neurodevelopment and cancer progression. It serves as a valuable tool for research applications focused on kinase signaling pathways and their implications in disease states.
Product Information
Catalog NumA35074
FormulaC18H17N5O3S
Molecular Weight383.42
CAS Number1365986-44-2
SMILESO=C(NC/1=O)SC1=C\C2=CNC(C(C3=CC=C(N4CCNCC4)N=C3)=C2)=O
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