Fig. 1 · Structure
Documents & Downloads
Thalidomide-5-Cl
Thalidomide Analog
Thalidomide-5-Cl is a thalidomide analog that serves as a useful tool in research targeting protein degradation via the PROTAC (proteolysis-targeting chimera) mechanism. It exhibits biological activity through its interaction with cereblon, leading to the recruitment of E3 ligases and subsequent ubiquitination of target proteins. This compound is valuable for studies aimed at understanding the modulation of cellular processes and the development of innovative therapeutic strategies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Degrader |
| CAS Number | 835616-62-1 |
| Applications | Thalidomide Analog |
| Formula | C13H9ClN2O4 |
| Molecular Weight | 292.67 |
| SMILES | O=C1C2=CC=C(C=C2C(N1C3C(NC(CC3)=O)=O)=O)Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.