Fig. 1 · Structure
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Thalidomide-pyrrolidine hydrochloride
E3 Ligase Ligand
Thalidomide-pyrrolidine hydrochloride is an E3 ligase ligand that serves as a key building block for the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates targeted protein degradation by engaging with E3 ligases, offering a valuable tool for studies in protein regulation and the development of novel therapeutic strategies. Its application in chemical biology makes it an important reagent for researchers exploring targeted degradation pathways.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Ligand / Binder |
| CAS Number | 2616553-35-4 |
| Applications | E3 Ligase Ligand |
| Formula | C15H14ClN3O4 |
| Molecular Weight | 335.74 |
| SMILES | O=C1NC(C(CC1)N2C(C3=C(C2=O)C=C(CNC4)C4=C3)=O)=O.[H]Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.