Thalidomide-1-Me,4-OH is an analogue of Thalidomide, featuring an additional methyl group on the glutarimide moiety. This modification abolishes its interaction with the E3 ubiquitin ligase, cereblon (CRBN), which is critical for the ubiquitination and subsequent proteolytic degradation of target proteins. Thalidomide itself is well-known for its immunomodulatory and anti-inflammatory properties, making Thalidomide-1-Me,4-OH a valuable tool for investigating the molecular mechanisms of CRBN-mediated drug action and cellular protein regulation in research applications.
Thalidomide-1-Me,4-OH is an analogue of Thalidomide, featuring an additional methyl group on the glutarimide moiety. This modification abolishes its interaction with the E3 ubiquitin ligase, cereblon (CRBN), which is critical for the ubiquitination and subsequent proteolytic degradation of target proteins. Thalidomide itself is well-known for its immunomodulatory and anti-inflammatory properties, making Thalidomide-1-Me,4-OH a valuable tool for investigating the molecular mechanisms of CRBN-mediated drug action and cellular protein regulation in research applications.
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