Catalog No.
Product Name
Application
Product Information
Citations
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CRBN ligand
Pomalidomide 7'OMe is a potent CRBN ligand that functions as an E3 ligase recruiter, facilitating the targeted degradation of proteins through the ubiquitin-proteasome pathway. Its unique structure allows for the potential linkage to BRD9 ligands, making it an essential component in the synthesis of PROTAC BRD9 degrader-9. This compound is valuable for research applications in targeted protein degradation and cellular signaling pathways. -
Ligands for E3 Ligase
CRBN ligand-190 is a ligand for the CRBN-type E3 ubiquitin ligase, facilitating the targeted ubiquitination and degradation of proteins. This compound is instrumental in the development of PROTACs (proteolysis-targeting chimeras), notably for synthesizing PROTAC HPK1 Degrader-7. Its utility in protein degradation strategies makes it a valuable tool for research in targeted therapy and protein homeostasis. -
E3 Ubiquitin Ligase Ligand
E3 Ligase Ligand 43 functions as a ligand for E3 ubiquitin ligase ACBI3. This compound is essential for the synthesis of Proteolysis Targeting Chimeras (PROTACs), allowing for targeted protein degradation. Its application is significant in cellular studies investigating protein turnover, signaling pathways, and disease mechanisms. -
Ligand for E3 Ligase
E3 ligase Ligand 7 is a selective ligand for E3 ligase, facilitating targeted protein degradation through the formation of PROTACs (proteolysis-targeting chimeras). This compound serves as a key building block for the synthesis of PROTAC BET Degrader-12, enabling researchers to study the modulation of BET protein functions. E3 ligase Ligand 7 is valuable for applications in drug discovery and development, particularly in exploring therapeutic strategies for diseases associated with aberrant protein levels. -
VHL Ligand
VHL-SF2 is a selective ligand for the von Hippel-Lindau (VHL) protein, facilitating the synthesis of PROTACs (proteolysis-targeting chimeras). By engaging the VHL E3 ubiquitin ligase, VHL-SF2 promotes the targeted degradation of specific proteins, making it a valuable tool in drug discovery and development. This compound is essential for researchers investigating targeted protein degradation and enhancing the therapeutic potential of protein-based treatments. -
Ligands for E3 Ligase
CRBN ligand-1 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN). This compound plays a critical role in mediating protein degradation through the ubiquitin-proteasome pathway, making it an important tool for studying protein homeostasis and cellular signaling mechanisms. It is utilized in research applications focused on targeted protein degradation and the development of novel therapeutics for diseases related to dysregulated protein dynamics. -
Ligands for E3 Ligase Chemical
cIAP1 ligand 4 is an E3 ligase ligand designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the targeted degradation of proteins by engaging the cellular ubiquitin-proteasome system. Its application in molecular biology research allows for advanced manipulation of protein levels, enhancing studies related to protein function and cellular signaling pathways. -
E3 Ubiquitin Ligase Ligand
E3 ligase Ligand 49 is an E3 ubiquitin ligase ligand that plays a critical role in the development of PROTAC (Proteolysis Targeting Chimeras) technology. This compound is specifically designed for the synthesis of PROTACs targeting XPO1, facilitating targeted protein degradation in various biological contexts. Its application is particularly relevant in studies focusing on protein regulation and degradation pathways, providing valuable insights into cellular processes and disease mechanisms. -
Ligand for E3 Ligase
Pomalidomide-6-O-CH3 is a modified derivative of Pomalidomide that serves as a ligand for the E3 ubiquitin ligase cereblon (CRBN). This compound plays a crucial role in the recruitment of CRBN, facilitating targeted protein degradation through the formation of PROTACs when linked to other protein ligands. Its application in the study of protein turnover and degradation pathways makes it a valuable tool in chemical biology and therapeutic research. -
Ligands for E3 Ligase
E3 Ligase Ligand 29 serves as a ligand for E3 ligases, facilitating the ubiquitination process by targeting specific substrates for proteasomal degradation. This compound plays a crucial role in modulating cellular protein levels and has significant applications in research focused on protein homeostasis, cancer biology, and signal transduction pathways. The ability to selectively influence E3 ligase activity makes it a valuable tool for studying ubiquitin-mediated mechanisms. -
Ligands for E3 Ligase
Dihydrouracil-Ph-2-Me-piperidine serves as a ligand for E3 ligase, facilitating targeted protein degradation through the PROTAC technology. It is instrumental in synthesizing the PROTAC HPK1 Degrader-6, which can be employed in studies aimed at modulating cellular pathways by specifically degrading target proteins. This compound is valuable for researchers investigating the therapeutic potential of PROTACs and E3 ligase-mediated protein degradation in various biological contexts. -
E3 Ligase Ligand
Thalidomide-C4-N2-C2-N3 is a potent E3 ligase ligand that facilitates the formation of PROTAC molecules. This compound is designed to bind to target protein ligands through a flexible linker, enabling the degradation of specific substrates such as sEH via the PROTAC mechanism. Its ability to modulate protein levels provides valuable utility in research applications focused on targeted protein degradation and therapeutic potential in various disease contexts. -
Ligands for E3 Ligase
CRBN ligand-181 is an E3 ubiquitin ligase ligand designed to engage the cereblon (CRBN) target. This compound serves as a key building block for the development of proteolysis-targeting chimeras (PROTACs), enabling targeted degradation of specific proteins within cellular systems. Its application in research facilitates the study of targeted protein degradation and modulation of cellular pathways. -
Ligand for E3 Ligase
CRBN ligand-200 is a ligand for the E3 ubiquitin ligase cereblon (CRBN) that facilitates the recruitment of the cereblon protein. This compound can be conjugated to a target protein ligand through a linker to create a PROTAC (Proteolysis Targeting Chimera), enabling targeted degradation of specific proteins. Research applications include studying protein turnover processes and developing novel therapeutic strategies in targeted protein degradation. -
Ligand for E3 Ligase
CRBN ligand-625 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), designed to facilitate the recruitment of CRBN to specific target proteins. This compound can be utilized in the development of proteolysis-targeting chimeras (PROTACs), enabling the selective degradation of proteins of interest. CRBN ligand-625 is essential for research in targeted protein degradation and protein homeostasis studies. -
Ligand for E3 Ligase
CRBN ligand-363 is a specific ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be conjugated to target protein ligands through a linker to create PROTACs, enabling targeted protein degradation. It serves as a valuable tool in research applications involving protein modulation and degradation pathways. -
Ligand for E3 Ligase
CRBN ligand-557 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be utilized in conjunction with a target protein ligand via a linker to create proteolysis-targeting chimeras (PROTACs). It serves a crucial role in targeted protein degradation research, enabling the study of protein modulation and therapeutic interventions in various biological contexts. -
Ligand for E3 Ligase
CRBN ligand-202 functions as a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein in cellular systems. This compound can be conjugated to a target protein ligand through a linker, enabling the formation of a PROTAC (Proteolysis Targeting Chimera) to effectively promote targeted protein degradation. Its application in research supports the exploration of targeted protein modulation and therapeutic strategies in various biological contexts. -
Ligand for E3 Ligase
CRBN ligand-436 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be utilized in the development of PROTACs (proteolysis-targeting chimeras) by linking it to a target protein ligand through a suitable linker. Its application includes targeted protein degradation studies, providing an innovative approach for modulating protein levels in various biological contexts. -
Ligand for E3 Ligase
CRBN Ligand-694 is a potent ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to specific target proteins. This compound can be conjugated with a target protein ligand through a linker to create a PROTAC (Proteolysis Targeting Chimera), enabling targeted protein degradation. Its applications are valuable in chemical biology and therapeutic research, particularly in the study of protein modulation and the ubiquitin-proteasome system. -
Ligand for E3 Ligase
CRBN ligand-448 is a ligand for the E3 ubiquitin ligase known as cereblon (CRBN). This compound facilitates the recruitment of cereblon, allowing for targeted protein degradation by forming a proteolysis-targeting chimeric (PROTAC) molecule when conjugated to a target protein ligand via a linker. Its utility in research includes investigating protein turnover and the modulation of cellular signaling pathways. -
Ligand for E3 Ligase
CRBN Ligand-333 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. This chemical compound is designed to be conjugated with a target protein ligand through a linker, enabling the formation of proteolysis-targeting chimeras (PROTACs). Its application in targeted protein degradation research offers significant potential for therapeutic intervention and advancing drug discovery initiatives. -
Ligand for E3 Ligase
CRBN ligand-253 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to target proteins. This compound can be conjugated to a target protein ligand through a linker, enabling the formation of a PROTAC (proteolysis-targeting chimera). CRBN ligand-253 is primarily utilized in research applications focused on targeted protein degradation and the modulation of protein levels within cellular contexts. -
Ligand for E3 Ligase
CRBN ligand-332 is a novel ligand for the E3 ubiquitin ligase cereblon (CRBN). This compound facilitates the recruitment of the CRBN protein, allowing for targeted protein degradation applications. CRBN ligand-332 can be conjugated to a target protein ligand through a linker to create a PROTAC, making it a valuable tool for studying protein function and regulation in chemical biology and drug discovery. -
Ligand for E3 Ligase
CRBN ligand-348 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein for targeted protein degradation. This compound can be utilized to conjugate with a target protein ligand through a linker, enabling the formation of PROTAC molecules. Its application is particularly relevant in drug discovery and development, particularly for studies involving targeted protein degradation mechanisms. -
Ligand for E3 Ligase
CRBN ligand-211 is a specific ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound serves as a crucial component for the development of proteolysis-targeting chimeras (PROTACs) by linking to target protein ligands through a suitable linker. It is valuable for research in targeted protein degradation and cellular regulation studies. -
Ligand for E3 Ligase
Desamino lenalidomide-Bpin is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of this critical protein for targeted protein degradation applications. Its chemical structure enables the conjugation of Desamino lenalidomide-Bpin to a target protein ligand via a linker, forming a proteolysis-targeting chimera (PROTAC). This compound is essential for research in areas such as targeted therapy and degradation of disease-related proteins. -
Ligand for E3 Ligase
Desamino lenalidomide[3,4-g]piperidine is a ligand for the E3 ubiquitin ligase cereblon (CRBN), playing a critical role in targeted protein degradation. This compound facilitates the recruitment of the cereblon protein, enabling the design of bifunctional therapeutic molecules when linked to a target protein ligand through a suitable linker. It serves as a valuable tool in research applications focused on the modulation of protein homeostasis and therapeutic strategies against various diseases. -
Ligand for E3 Ligase
CRBN ligand-351 is a specific ligand for the E3 ubiquitin ligase cereblon (CRBN). It effectively recruits the cereblon protein and can be conjugated to a target protein ligand through a linker, facilitating the formation of a PROTAC (Proteolysis Targeting Chimera). This compound is valuable for research applications focused on targeted protein degradation and modulation of cellular pathways. -
Ligand for E3 Ligase
(R)-Desamino lenalidomide-5-Br is a potent ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of this protein in cellular contexts. This compound can be utilized in the design of PROTACs (proteolysis targeting chimeras) by linking it to a target protein ligand through a suitable linker. Its unique mechanism allows for targeted protein degradation, making it valuable for research applications in drug discovery and therapeutic development. -
Ligand for E3 Ligase
CRBN ligand-504 is a specific ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be conjugated to a target protein ligand through a linker, enabling the development of proteolysis-targeting chimeras (PROTACs). It is a valuable tool in chemical biology for studying targeted protein degradation and ubiquitination processes. -
Ligand for E3 Ligase
CRBN ligand-604 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of cereblon for targeted protein degradation. It can be conjugated with a target protein ligand through a linker, enabling the formation of a PROTAC (proteolysis-targeting chimera). This reagent is instrumental in research applications focused on exploring novel therapeutic strategies for modulating protein levels and identifying potential drug targets. -
Ligand for E3 Ligase
CRBN ligand-495 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of cereblon to specific target proteins. This compound can be utilized in the construction of PROTACs (proteolysis-targeting chimeras) by linking it to a target protein ligand via an appropriate linker. The application of CRBN ligand-495 offers significant potential in targeted protein degradation studies and therapeutic development within cellular and molecular biology research. -
Ligand for E3 Ligase
CRBN ligand-204 is a potent ligand for the E3 ubiquitin ligase cereblon (CRBN). This compound facilitates the recruitment of cereblon, enabling targeted protein degradation through the formation of proteolysis-targeting chimeras (PROTACs) when linked to a target protein ligand. CRBN ligand-204 is valuable in research applications involving the modulation of protein levels and the study of ubiquitin-mediated pathways. -
Thalidomide Analog
3-Azathalidomide is a Thalidomide analog that primarily targets the E3 ubiquitin ligase, making it a valuable tool in protein degradation studies. This compound exhibits biological activity that facilitates the development of PROTACs (proteolysis-targeting chimeras), enabling targeted protein degradation in various cellular contexts. Its application is particularly relevant in drug discovery and targeted therapeutics research, where modulation of protein levels is essential for understanding disease mechanisms and therapeutic interventions. -
Ligand for E3 Ligase
CRBN ligand-714 is an E3 ubiquitin ligase cereblon (CRBN) ligand that facilitates the recruitment of the cereblon protein. This compound can be utilized to develop PROTACs by linking it to a target protein ligand via a linker. CRBN ligand-714 is valuable in research focused on protein degradation and targeted protein modulation for therapeutic applications. -
Ligand for E3 Ligase
CRBN ligand-515 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN for targeted protein degradation. This compound can be effectively linked to a target protein ligand through a linker to construct a PROTAC (proteolysis-targeting chimera), enabling precise modulation of protein levels in cellular systems. It is valuable for research applications focused on protein dynamics, ubiquitin-proteasome pathway studies, and therapeutic development involving targeted protein degradation strategies. -
Thalidomide Analog
Thalidomide-5-Cl is a thalidomide analog that serves as a useful tool in research targeting protein degradation via the PROTAC (proteolysis-targeting chimera) mechanism. It exhibits biological activity through its interaction with cereblon, leading to the recruitment of E3 ligases and subsequent ubiquitination of target proteins. This compound is valuable for studies aimed at understanding the modulation of cellular processes and the development of innovative therapeutic strategies. -
Ligand for E3 Ligase
CRBN ligand-702 is an E3 ubiquitin ligase cereblon (CRBN) ligand that facilitates the recruitment of the cereblon protein. This compound can be conjugated to a target protein ligand using a suitable linker to create a proteolysis-targeting chimera (PROTAC). Its application in targeted degradation strategies makes it valuable for research in the fields of protein homeostasis and targeted therapy development. -
Ligand for E3 Ligase
CRBN ligand-726 is a ligand for the E3 ubiquitin ligase cereblon (CRBN) that facilitates the recruitment of the cereblon protein. It can be utilized to create PROTACs by linking it to target protein ligands through a suitable linker. This compound is instrumental in studies focused on protein degradation and targeted therapies, particularly in cancer research. -
Ligands for E3 Ligase
LC3 ligand-2 is a ligand for E3 ligases that facilitates targeted protein degradation through the PROTAC system. This compound is utilized in the synthesis of PROTAC PDEδ autophagic degrader 1, providing a valuable tool for researchers studying autophagy and protein homeostasis. Its application extends to the development of novel therapeutic strategies for diseases associated with protein misfolding and aggregation. -
Ligand for E3 Ligase
CRBN ligand-447 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of this protein for targeted protein degradation. It can be conjugated to a target protein ligand through a linker to create a PROTAC (proteolysis-targeting chimera), enabling selective degradation of specific proteins in cellular assays. This compound is valuable for research in targeted therapies and protein homeostasis studies. -
Ligand for E3 Ligase
CRBN ligand-328 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be conjugated to a target protein ligand through a linker to create PROTACs, which are valuable tools for targeted protein degradation studies. CRBN ligand-328 is essential for research applications focused on therapeutic strategies that employ protein modulation and manipulation within cellular pathways. -
Ligand for E3 Ligase
Hydrouracil-3-PhOH is a ligand targeting the E3 ubiquitin ligase cereblon (CRBN). It facilitates the recruitment of cereblon to specific target proteins, enabling the construction of proteolysis-targeting chimeras (PROTACs) when conjugated with an appropriate target protein ligand through a linker. This compound is valuable for research applications in protein degradation and modulation of cellular pathways. -
Ligand for E3 Ligase
CRBN ligand-730 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound is designed to be linked with a target protein ligand via a linker to generate a PROTAC (PROteolysis TArgeting Chimeras), which enhances targeted protein degradation. It serves as a valuable tool for research in protein interaction and degradation mechanisms. -
Ligand for E3 Ligase
CRBN Ligand-744 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be conjugated to a target protein ligand through a linker, enabling the development of PROTACs (proteolysis-targeting chimeras) for targeted protein degradation studies. Its primary applications include investigating cellular processes mediated by ubiquitination and developing therapeutic strategies for diseases related to protein misfolding and aggregation. -
Ligand for E3 Ligase
CRBN ligand-512 is a ligand for the E3 ubiquitin ligase cereblon (CRBN). This compound facilitates the recruitment of the CRBN protein, enabling the formation of proteolysis-targeting chimeras (PROTACs) when linked to a target protein ligand through a suitable linker. It plays a crucial role in targeted protein degradation research applications, contributing to advancements in cellular signaling studies and therapeutic development. -
Ligand for E3 Ligase
CRBN ligand-519 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN). It is designed to facilitate the recruitment of cereblon, allowing for targeted protein degradation through the formation of PROTAC (Proteolysis Targeting Chimeras) when linked to a target protein ligand via a suitable linker. This compound serves as a valuable tool for elucidating cellular mechanisms and developing innovative therapeutic strategies by modulating protein levels in various biological contexts. -
Ligand for E3 Ligase
CRBN ligand-474 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be conjugated with a target protein ligand through a linker to create a proteolysis-targeting chimera (PROTAC). CRBN ligand-474 is valuable in studies of targeted protein degradation and ubiquitin-proteasome pathway modulation, providing insights into cellular regulation and therapeutic applications in various diseases. -
Ligand for E3 Ligase
CRBN ligand-600 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to target proteins. This compound plays a crucial role in the development of PROTACs (proteolysis-targeting chimeras), enabling targeted degradation of specific proteins through ubiquitin-proteasome pathways. It is valuable for researchers investigating protein regulation and potential therapeutic interventions in various diseases.
