E3 Ligase Ligands

Cat. No.

A80514

CAS No.

2359705-88-5

Lenalidomide-F

Lenalidomide-F is an E3 ligase ligand that targets cereblon, facilitating the development of PROTAC molecules. It is specifically designed for use with LWY713, a potent degrader of FLT3, exhibiting a DC50 value of 0.64 nM. This compound selectively induces the degradation of FLT3 through proteasome-dependent mechanisms. Lenalidomide-F is valuable for research applications focused on targeted protein degradation and the therapeutic potential of PROTACs in oncology.

Cat. No.

A80515

CAS No.

2582979-82-4

Glutarimide-(1-oxoisoindoline-5-carbaldehyde)

Glutarimide-(1-oxoisoindoline-5-carbaldehyde) functions as a ligand for the E3 ubiquitin ligase cereblon (CRBN). This compound facilitates the recruitment of the cereblon protein, enabling targeted protein degradation approaches. It can be conjugated with specific target protein ligands through a linker, making it suitable for the development of PROTACs in proteomics research and drug discovery applications.

Cat. No.

A80516

CAS No.

1416990-10-7

Desamino lenalidomide-7-OH

Desamino lenalidomide-7-OH is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of cereblon to target proteins. This compound can be utilized in the design of PROTACs by linking it to a target protein ligand via a suitable linker. Its biological activity enables selective modulation of protein levels, making it a valuable tool in targeted protein degradation research applications.

Cat. No.

A80517

CAS No.

959150-64-2

2-(2,6-Dioxopiperidin-3-yl)-4-iodoisoindoline-1,3-dione

2-(2,6-Dioxopiperidin-3-yl)-4-iodoisoindoline-1,3-dione is a Thalidomide analog that features an iodine substitution on the isoindoline structure. This compound exhibits significant biological activity related to anti-inflammatory and anti-angiogenic properties. It is primarily utilized in research applications investigating the mechanisms of action of Thalidomide and its derivatives in various therapeutic contexts, particularly in cancer and autoimmune disorders.

Cat. No.

A80518

CAS No.

2438239-34-8

Lenalidomide-4-Br-7-fluoro

Lenalidomide-4-Br-7-fluoro is a derivative of Lenalidomide featuring bromine and fluorine substituents on the benzyl ring. This compound exhibits immunomodulatory properties, enhancing immune responses and exhibiting anti-tumor activity. It can be utilized in research to investigate the mechanisms of action of Lenalidomide and its analogs, as well as their potential therapeutic applications in hematological malignancies.

Cat. No.

A80519

CAS No.

2446913-96-6

1-(4-Pip-Ph)-DHP-dione

1-(4-Pip-Ph)-DHP-dione is a ligand specifically designed for targeting E3 ligases. It plays a crucial role in the development of proteolysis-targeting chimeras (PROTACs), particularly in the synthesis of the HPK1 Degrader-2. This compound is valuable for research in targeted protein degradation and provides insights into E3 ligase-mediated cellular processes.

Cat. No.

A80520

CAS No.

2171519-15-4

Desamino lenalidomide-5-COOH

Desamino lenalidomide-5-COOH is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN). This compound facilitates the recruitment of cereblon to target proteins, enabling the formation of PROTACs (proteolysis-targeting chimeras) through a strategic linker attachment. Desamino lenalidomide-5-COOH is instrumental in studying targeted protein degradation pathways and has applications in drug discovery and therapeutic development.

Cat. No.

A80522

CAS No.

1352827-50-9

N-Methylated pomalidomide

Synonyms: Pomalidomide-methyl

N-Methylated pomalidomide acts as a selective ligand for cereblon (CRBN). This derivative of pomalidomide lacks the ability to recruit CRBN, making it a valuable negative control in studies involving pomalidomide. Additionally, N-methylated pomalidomide can be utilized in the synthesis of PROTACs, thereby assisting researchers in the exploration of targeted protein degradation pathways and mechanisms.

Cat. No.

A80523

CAS No.

1416990-09-4

Desamino lenalidomide-6-OH

Desamino lenalidomide-6-OH is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. This compound can be utilized in the synthesis of PROTACs by linking it to a target protein ligand through a suitable linker. Its applications include studies in targeted protein degradation and therapeutic strategies in cancer research.

Cat. No.

A80524

CAS No.

2358775-81-0

VH 101, thiol

VH 101, thiol serves as a selective VHL ligand, primarily utilized in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound enables the targeted degradation of specific proteins by harnessing the ubiquitin-proteasome system, making it instrumental in drug discovery and therapeutic research. Its robust binding affinity and specificity towards VHL provide an effective tool for studies aimed at elucidating protein regulation mechanisms and developing novel treatments for various diseases.

Cat. No.

A80525

CAS No.

2641512-74-3

CRBN ligand-395

CRBN ligand-395 is a potent ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to target proteins. This compound can be conjugated with a target protein ligand using a linker to form a proteolysis-targeting chimera (PROTAC), enabling the targeted degradation of specific proteins. CRBN ligand-395 is valuable in research applications involving protein degradation and modulation of cellular pathways.

Cat. No.

A80526

CAS No.

2244684-42-0

VH032-OH

VH032-OH is a ligand for the E3 ligase Von Hippel-Lindau (VHL), enabling targeted protein degradation. This compound can be utilized in the development of PROTACs (Proteolysis Targeting Chimeras) by linking it to target proteins. VH032-OH facilitates the selective ubiquitination and subsequent proteasomal degradation of substrate proteins, making it a valuable tool for investigating protein turnover and cellular regulation in various research applications.

Cat. No.

A80527

CAS No.

1472731-41-1

E3 ligase Ligand 56

E3 Ligase Ligand 56 is a specific ligand for the E3 ubiquitin ligase Cereblon, facilitating targeted protein degradation through proteolysis-targeting chimeras (PROTACs). This compound is instrumental in the synthesis of PROTAC CDK9 degrader-11, supporting research in targeted degradation mechanisms and their applications in cellular processes. Its utility in developing novel therapeutics makes it a valuable reagent for studies in oncology and pharmacology.

Cat. No.

A80528

CAS No.

444287-56-3

E3 ligase Ligand 23

E3 Ligase Ligand 23 is a cereblon binder that facilitates the degradation of Ikaros and Aiolos through the ubiquitin-proteasome pathway. This compound is instrumental in probing the mechanisms of targeted protein degradation and the role of cereblon in modulating protein levels. It is valuable for research applications involving the regulation of immune responses and hematological malignancies.

Cat. No.

A80529

CAS No.

1547162-44-6

Pomalidomide-6-OH

Pomalidomide-6-OH is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating targeted protein degradation through the proteolysis-targeting chimera (PROTAC) approach. This compound is instrumental in research applications focused on the selective modulation of protein levels within cellular contexts, contributing to studies in cancer and other diseases. Pomalidomide-6-OH serves as a valuable tool for investigating the biochemical pathways regulated by CRBN.

Cat. No.

A80530

CAS No.

191732-75-9

3-(7-Amino-1-oxoisoindolin-2-yl)piperidine-2,6-dione

3-(7-Amino-1-oxoisoindolin-2-yl)piperidine-2,6-dione is a Lenalidomide analog that serves as a valuable tool in PROTAC research. This compound selectively modulates protein degradation pathways, making it instrumental in the development of targeted therapeutics. Its structural similarity to Lenalidomide allows for the exploration of novel therapeutic applications in oncology and immunology.

Cat. No.

A80531

CAS No.

2304753-45-3

CRBN ligand-788

CRBN ligand-788 is an E3 ubiquitin ligase cereblon (CRBN) ligand that facilitates the recruitment of the cereblon protein. This compound can be conjugated to a target protein ligand via a linker, enabling the formation of a proteolysis-targeting chimeric (PROTAC) molecule. CRBN ligand-788 is primarily utilized in research focused on targeted protein degradation and harnessing the ubiquitin-proteasome system for therapeutic interventions.

Cat. No.

A80532

CAS No.

2758431-93-3

Pomalidomide 5'-piperazine-4-methylpiperidine dihydrochloride

Pomalidomide 5'-piperazine-4-methylpiperidine dihydrochloride is a ligand targeting cereblon (CRBN) within the E3 ubiquitin ligase complex. This compound facilitates the recruitment of CRBN, making it a valuable tool for the development of PROTACs (proteolysis-targeting chimeras) through linker conjugation. It holds potential applications in research related to targeted protein degradation and the study of protein homeostasis in various diseases, particularly in cancer.

Cat. No.

A80533

CAS No.

2154343-24-3

CRBN ligand-661

CRBN ligand-661 is a ligand for the E3 ubiquitin ligase cereblon (CRBN) that facilitates the targeted recruitment of the cereblon protein. This compound is designed for use in the development of PROTACs (Proteolysis Targeting Chimeras), linking to specific target proteins to promote their degradation via the ubiquitin-proteasome pathway. Its potential applications include studies in targeted protein degradation and the modulation of protein levels in various biological contexts.

Cat. No.

A80534

CAS No.

2287259-68-9

Desamino lenalidomide-COOH

Desamino lenalidomide-COOH is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the targeted regulation of protein degradation. This compound can be conjugated to a target protein ligand through a linker to create a PROTAC (Proteolysis Targeting Chimera), enabling the selective modulation of protein functions in cellular and in vivo studies. It is a valuable tool for research applications in protein homeostasis and therapeutic development.

Cat. No.

A80535

CAS No.

911109-85-8

(S)-Thalidomide 4-fluoride

(S)-Thalidomide 4-fluoride is a selective ligand for the cereblon (CRBN) E3 ligase. This compound is utilized in the synthesis of DeDPP4, making it a valuable tool in research related to protein degradation and the development of targeted therapeutics. Its interaction with the E3 ligase pathway underscores its potential applications in cellular biology and drug discovery initiatives.

Cat. No.

A80536

CAS No.

2768326-37-8

C5 Lenalidomide-CH3

C5 Lenalidomide-CH3 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. This compound can be conjugated to a target protein ligand through a linker to generate a PROTAC, thereby enabling targeted protein degradation. Its unique mechanism offers valuable applications in research focused on protein modulation and degradation pathways.

Cat. No.

A80537

CAS No.

2866307-09-5

Desamino lenalidomide-5-CO

Desamino lenalidomide-5-CO is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), enabling the recruitment of the CRBN protein. This compound can be conjugated to target protein ligands through a linker to facilitate the formation of proteolysis-targeting chimeras (PROTACs). Its application in protein degradation studies makes it a valuable tool for exploring therapeutic strategies in various diseases, including cancer.

Cat. No.

A80538

CAS No.

2229976-08-1

3-(7-Bromo-1-oxoisoindolin-2-yl)piperidine-2,6-dione

3-(7-Bromo-1-oxoisoindolin-2-yl)piperidine-2,6-dione is a Lenalidomide analog targeting the ubiquitin-proteasome system. This compound exhibits notable biological activity in the development of PROTACs (proteolysis-targeting chimeras), providing a valuable tool for research into targeted protein degradation. Its structural features enhance the potential for therapeutic applications in oncology and related fields.

Cat. No.

A80539

CAS No.

444287-40-5

Thalidomide-CH2NH2 hydrochloride

Thalidomide-CH2NH2 hydrochloride is a Thalidomide analogue characterized by a primary amine functionality. This compound demonstrates potential biological activity by modulating immune responses and influencing angiogenesis. It is suitable for research applications investigating mechanisms of action related to inflammatory diseases, cancer treatment, and teratogenic effects associated with Thalidomide derivatives.