SJF-0661 is a variant of the von Hippel-Lindau (VHL) protein ligand that lacks the capacity for targeted degradation. Serving as an essential control reagent, it is useful for studies involving VHL ubiquitin ligase ligands. This compound is synthesized by inverting the stereocenter of the critical hydroxyproline moiety in the original VHL ligand, allowing researchers to evaluate the specific activities of VHL ligands in various biological contexts.
SJF-0661 is a variant of the von Hippel-Lindau (VHL) protein ligand that lacks the capacity for targeted degradation. Serving as an essential control reagent, it is useful for studies involving VHL ubiquitin ligase ligands. This compound is synthesized by inverting the stereocenter of the critical hydroxyproline moiety in the original VHL ligand, allowing researchers to evaluate the specific activities of VHL ligands in various biological contexts.
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