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Thalidomide-5-carbaldehyde

Thalidomide Analog

Thalidomide-5-carbaldehyde is a Thalidomide analog featuring an aldehyde functional group. It actively interacts with E3 ligases, facilitating the ubiquitination and degradation of specific target proteins, thereby contributing to cellular regulation. The aldehyde group exhibits high reactivity towards amine nucleophiles, enabling reductive amination and other chemical modifications, making it a valuable tool for research in protein degradation pathways and therapeutic development.

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Specifications

Manufacturer	Adooq Bioscience
CAS Number	1447701-63-4
Applications	Thalidomide Analog
Formula	C₁₄H₁₀N₂O₅
Molecular Weight	286.24
SMILES	O=CC1=CC2=C(C(N(C(CC3)C(NC3=O)=O)C2=O)=O)C=C1

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.