Catalog No.
Product Name
Application
Product Information
Citations
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Ligand for E3 Ligase
CRBN ligand-538 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to target proteins. This compound can be conjugated to a target protein ligand through a linker, enabling the formation of PROTACs for targeted protein degradation studies. CRBN ligand-538 is valuable in the investigation of protein regulation and therapeutic interventions in various biological contexts. -
Ligand for E3 Ligase
CRBN ligand-590 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the targeted recruitment of the CRBN protein. This compound can be conjugated to a target protein ligand through a linker, enabling the formation of a proteolysis-targeting chimera (PROTAC). CRBN ligand-590 is valuable for research applications focused on targeted protein degradation and the modulation of cellular protein levels. -
Ligand for E3 Ligase
CRBN ligand-592 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be conjugated to target protein ligands through a linker, enabling the formation of Proteolysis Targeting Chimeras (PROTACs). CRBN ligand-592 serves as a valuable tool in targeted protein degradation research, allowing for the modulation of protein levels within cellular systems. -
Ligand for E3 Ligase
CRBN ligand-377 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN). It facilitates the recruitment of the CRBN protein, enabling targeted protein degradation when conjugated with a target protein ligand through a linker. This compound is valuable for research applications involving PROTAC (Proteolysis Targeting Chimeras) development, which are instrumental in the study of protein regulation and modulation in various biological contexts. -
Ligand for E3 Ligase
CRBN ligand-428 is a high-affinity ligand for the E3 ubiquitin ligase cereblon (CRBN). It facilitates the recruitment of CRBN to target proteins, enabling the formation of PROTACs (Proteolysis Targeting Chimeras) for targeted protein degradation. This compound serves as a valuable tool for researchers investigating protein regulation and degradation pathways. Its applications include exploring therapeutic strategies in cancer and other diseases through targeted modulation of protein levels. -
Ligand for E3 Ligase
CRBN ligand-498 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of this protein for targeted protein degradation. Its unique structure allows for the formation of PROTACs when conjugated with a target protein ligand through a linker. This compound is instrumental in advancing research on targeted therapies and protein modulation in various biological studies, providing a powerful tool for investigating the dynamics of protein interactions and degradation pathways. -
Ligand for E3 Ligase
CRBN ligand-477 is a ligand for cereblon (CRBN), an E3 ubiquitin ligase that plays a critical role in protein degradation pathways. This compound facilitates the recruitment of the CRBN protein, enabling the targeted degradation of specific proteins when linked to a target protein ligand via a suitable linker. CRBN ligand-477 is valuable in research applications involving targeted protein degradation and PROTAC development. -
Ligand for E3 Ligase
CRBN ligand-267 is an effective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be conjugated with a target protein ligand through a linker, enabling the formation of a proteolysis-targeting chimera (PROTAC). CRBN ligand-267 is valuable in research applications aimed at understanding protein degradation pathways and developing targeted therapies through the modulation of the ubiquitin-proteasome system. -
Ligand for E3 Ligase
CRBN ligand-423 is a ligand for the E3 ubiquitin ligase cereblon (CRBN) that plays a critical role in targeted protein degradation. This compound facilitates the recruitment of CRBN to specific target proteins and can be combined with target protein ligands through a linker to create a PROTAC (proteolysis-targeting chimera). Its application in the development of PROTACs provides valuable insights into the modulation of protein levels for therapeutic purposes in various biological research areas. -
Ligand for E3 Ligase
CRBN ligand-256 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of this essential protein. This compound can be utilized in the development of PROTACs by linking it to a target protein ligand through a suitable linker. CRBN ligand-256 is instrumental in studies focused on targeted protein degradation and the modulation of various biological pathways. -
Ligand for E3 Ligase
CRBN ligand-728 is a ligand that targets the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN proteins. This compound is pivotal in the development of proteolysis-targeting chimeras (PROTACs) by enabling the linkage of target protein ligands through a suitable linker. Its use in research focuses on exploring targeted protein degradation pathways, advancing the understanding of cellular regulation, and uncovering therapeutic strategies in various diseases. -
Ligand for E3 Ligase
CRBN ligand-544 is a potent ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be utilized in the development of proteolysis-targeting chimeras (PROTACs) by linking it to a target protein ligand through a suitable linker. Its application in targeted protein degradation studies makes it a valuable tool for researchers investigating ubiquitin-proteasome pathway dynamics and therapeutic interventions in various diseases. -
Ligand for E3 Ligase
CRBN ligand-579 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to specific protein targets. This compound can be utilized to create proteolysis-targeting chimeras (PROTACs) by linking it to a target protein ligand through a suitable linker. Its capacity to modulate protein degradation pathways makes CRBN ligand-579 valuable for studies involving targeted protein degradation and cellular signaling research. -
Ligand for E3 Ligase
CRBN ligand-554 is a specific ligand for the E3 ubiquitin ligase cereblon (CRBN), enabling the targeted recruitment of the cereblon protein. This compound can be conjugated to a ligand of a target protein through a suitable linker to create a PROTAC (proteolysis-targeting chimera). It is applicable in studies focused on targeted protein degradation and the modulation of cellular pathways associated with ubiquitination. -
Ligand for E3 Ligase
CRBN ligand-325 is a ligand specific for the E3 ubiquitin ligase cereblon (CRBN). This compound facilitates the recruitment of the CRBN protein, enabling targeted protein degradation through the formation of PROTACs when linked to a target protein ligand via a suitable linker. It is valuable for applications in ubiquitination research and drug discovery strategies aimed at modulating protein levels within cells. -
CRBN Ligand
CRBN ligand-186 is a potent ligand for the CRBN-type E3 ubiquitin ligase, facilitating the construction of PROTAC (proteolysis targeting chimeras). This compound is designed to promote targeted protein degradation by harnessing the ubiquitin-proteasome system. It is instrumental in research applications aimed at investigating protein interactions and elucidating cellular processes involved in metabolic regulation and disease pathogenesis. -
Ligand for E3 Ligase
CRBN ligand-556 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein for targeted protein degradation. This compound can be utilized in the construction of PROTACs (Proteolysis Targeting Chimeras) by linking to target protein ligands, enabling precise modulation of protein levels. Its application is essential in studying protein homeostasis, cellular signaling pathways, and therapeutic interventions in various diseases. -
Ligand for E3 Ligase
CRBN ligand-680 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to specific target proteins. This compound can be utilized in the development of PROTACs (Proteolysis Targeting Chimeras) by linking to target protein ligands through a suitable linker. Its application is particularly relevant in the study of targeted protein degradation and the modulation of cellular pathways. -
Ligand for E3 Ligase
CRBN ligand-690 serves as a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to target proteins. Through the conjugation of CRBN ligand-690 with a target protein ligand via a linker, it enables the formation of PROTACs (proteolysis-targeting chimeras). This reagent is instrumental in studies aimed at targeted protein degradation and the modulation of protein abundance in various biological systems. -
Ligand for E3 Ligase
CRBN ligand-273 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound is designed for use in the development of PROTACs by linking specifically to target protein ligands via a linker, enabling targeted degradation of proteins in cellular contexts. Its applications extend to studies in protein homeostasis and targeted protein degradation mechanisms. -
Ligand for E3 Ligase
CRBN ligand-289 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to target proteins. It serves as a critical component in the development of PROTACs (proteolysis-targeting chimeras) by enabling the targeted degradation of specific proteins through the ubiquitin-proteasome pathway. This reagent is essential for exploring cellular mechanisms and therapeutic applications involving targeted protein degradation. -
Ligand for E3 Ligase
CRBN ligand-500 is a ligand that targets the E3 ubiquitin ligase cereblon (CRBN) to facilitate the recruitment of this protein. It can be conjugated with a target protein ligand using a linker to create a proteolysis-targeting chimera (PROTAC). This compound is instrumental in studies aimed at protein degradation pathways and the modulation of cellular protein levels for therapeutic applications. -
Ligand for E3 Ligase
CRBN ligand-453 is an E3 ubiquitin ligase ligand that specifically targets cereblon (CRBN) to facilitate its recruitment. This compound is designed to be conjugated to a target protein ligand through a linker, enabling the formation of a PROTAC (Proteolysis Targeting Chimera). It provides a powerful tool for targeted protein degradation studies and is applicable in research aimed at modulating protein levels in various biological contexts. -
Ligand for E3 Ligase
CRBN ligand-369 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to target proteins. This compound can be conjugated to a target protein ligand through a linker, enabling the formation of proteolysis-targeting chimeras (PROTACs). CRBN ligand-369 is instrumental in studies focused on targeted protein degradation and therapeutic applications in various diseases. -
Ligand for E3 Ligase
CRBN Ligand-382 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be utilized in the development of proteolysis-targeting chimeras (PROTACs) by linking it to a target protein ligand through a suitable linker. Its application in targeted protein degradation research enables the exploration of innovative therapeutic strategies for various diseases. -
Ligand for E3 Ligase
CRBN ligand-208 is a small-molecule ligand targeting the E3 ubiquitin ligase cereblon (CRBN). It is designed to facilitate the recruitment of CRBN to target proteins, enabling targeted protein degradation through PROTAC technology. This compound is applicable in research focusing on protein regulation and cellular signaling pathways, providing a valuable tool for drug discovery and development. -
Ligand for E3 Ligase
CRBN ligand-753 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to target proteins. By attaching this compound to a target protein ligand through a linker, it can be utilized in the development of PROTACs (proteolysis-targeting chimeras). This compound is particularly valuable in research focused on targeted protein degradation and investigating the function of specific proteins involved in various biological processes. -
Ligand for E3 Ligase
CRBN ligand-686 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound is designed to be conjugated with a target protein ligand through a linker, enabling the formation of a proteolysis-targeting chimera (PROTAC). It has potential applications in targeted protein degradation studies and investigating protein homeostasis in various biological contexts. -
Ligand for E3 Ligase
CRBN ligand-478 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be conjugated to a target protein ligand through a linker to create a PROTAC (Proteolysis Targeting Chimeras). Its utility in controlling protein degradation makes it a valuable reagent for research applications in targeted protein modulation and therapeutic development. -
Ligand for E3 Ligase
CRBN ligand-228 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein for targeted protein degradation. It can be conjugated with a target protein ligand through a linker to generate a PROTAC (proteolysis-targeting chimera). This compound is instrumental in studies aimed at exploring the degradation of specific proteins and developing novel therapeutic strategies in cancer and other diseases. -
E3 Ligase Activator
Thalidomide-5-Br,6-F is a Thalidomide analogue functioning as an E3 ligase activator, promoting the ubiquitination of target proteins for proteolytic degradation. This compound enhances cellular pathways by modulating protein turnover, making it valuable in studies related to protein homeostasis and targeted degradation. Its unique structural features allow for potential further derivatization through substitution at the fluorine or bromine positions, offering avenues for the development of novel reagents. -
Ligand for E3 Ligase
CRBN ligand-620 functions as a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. This compound can be conjugated to a target protein ligand through a linker to create a PROTAC, which enhances targeted protein degradation. CRBN ligand-620 is relevant for research applications in protein modulation and therapeutic development, particularly in the study of protein homeostasis. -
Ligand for E3 Ligase
CRBN ligand-304 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to target proteins. This compound can be conjugated with a target protein ligand through a linker, enabling the formation of a PROTAC (Proteolysis Targeting Chimera). CRBN ligand-304 is instrumental in studying protein degradation pathways and the development of targeted therapeutics in cancer research and other therapeutic areas. -
Ligand for E3 Ligase
CRBN ligand-376 is a potent ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be utilized in the development of PROTACs by linking it to a target protein ligand through a suitable linker. Its application in targeted protein degradation provides valuable tools for elucidating protein functions and advancing therapeutic strategies. -
Ligand for E3 Ligase
CRBN ligand-552 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN). It facilitates the recruitment of the CRBN protein, enabling the targeted degradation of specific proteins in cellular systems. This compound can be utilized in the design of PROTACs (proteolysis-targeting chimeras) by linking it to a target protein ligand through a suitable linker, making it a valuable tool in drug discovery and development. -
Ligand for E3 Ligase
CRBN ligand-511 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the targeted recruitment of CRBN. This compound can be conjugated to target protein ligands through a linker to create proteolysis-targeting chimeras (PROTACs). Its application in degrading specific proteins makes it a valuable tool in chemical biology and therapeutic development for modulating cellular pathways. -
Ligand for E3 Ligase
CRBN ligand-359 is a specialized ligand for the E3 ubiquitin ligase cereblon (CRBN), enabling the recruitment of the cereblon protein for targeted degradation. This compound can be conjugated to a target protein ligand through a linker to construct a PROTAC, facilitating the selective modulation of protein levels in cellular studies. Its application in protein degradation research makes it a valuable tool for investigating protein function and developing novel therapeutic strategies. -
Ligands for E3 Ligase
CRBN ligand-111 acts as a ligand for the CRBN E3 ubiquitin ligase, facilitating targeted protein degradation through PROTAC (proteolysis-targeting chimeras) technology. This compound is vital for research focused on the modulation of ubiquitin-proteasome pathways, enabling the selective degradation of proteins involved in various cellular processes. Its application is particularly significant in studies aimed at therapeutic development, including cancer biology and neurodegenerative diseases. -
Thalidomide Analog
5-(2-Chloroacetamide) thalidomide is a Thalidomide analog that functions as an E3 ligase recruiter, facilitating the ubiquitination and targeted degradation of specific proteins. The inclusion of a chloroacetamide moiety enhances its reactivity towards thiol groups, potentially increasing its efficacy in modulating protein degradation pathways. This compound is of interest for research applications in targeted protein therapy and cancer biology, providing insights into the mechanisms of protein homeostasis. -
pVHL Ligand
VHL Ligand 35 is a selective ligand of the von Hippel-Lindau protein (pVHL) E3 ubiquitin ligase with a dissociation constant (Kd) of 0.291 μM. This compound effectively disrupts the protein-protein interaction between pVHL and hypoxia inducible factor 1α (HIF-1α), which is critical for regulating cellular responses to hypoxia. VHL Ligand 35 is valuable for research applications involving hypoxia signaling pathways and cancer biology, particularly in studies targeting the mechanisms of HIF regulation. -
Ligand for E3 Ligase
CRBN ligand-366 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to target proteins. This compound can be conjugated with a target protein ligand through a linker, enabling the formation of a PROTAC (Proteolysis Targeting Chimera). Its utility in protein degradation strategies makes it valuable for research in protein homeostasis and targeted therapeutics. -
Ligand for E3 Ligase
CRBN Ligand-723 is an efficient ligand targeting the E3 ubiquitin ligase cereblon (CRBN). This compound facilitates the recruitment of the cereblon protein and is designed to be conjugated to a target protein ligand through a linker to create a PROTAC (proteolysis-targeting chimera). It is valuable for research applications involving targeted protein degradation and cellular signaling pathways. -
Ligand for E3 Ligase
CRBN ligand-458 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. This compound is designed for use in the development of Proteolysis Targeting Chimeras (PROTACs) by linking to target protein ligands through a suitable linker. Its application enables targeted degradation of specific proteins, providing valuable tools for research in cancer biology and drug discovery. -
Ligand for E3 Ligase
CRBN ligand-522 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), serving as a tool for targeted protein degradation. It facilitates the recruitment of cereblon to specific target proteins through a linking mechanism, enabling the formation of PROTACs (proteolysis-targeting chimeras). This compound is valuable for research applications aimed at elucidating the role of targeted degradation in cellular processes and for drug discovery strategies focusing on protein modulation. -
Ligand for E3 Ligase
Desamino lenalidomide-6-C-COOH is a ligand for E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein in biochemical assays. This compound can be conjugated with a target protein ligand through a linker to create a proteolysis-targeting chimera (PROTAC), enabling targeted protein degradation. Its applications in drug development and cellular studies enhance understanding of protein regulation and therapeutic strategies. -
Ligands for E3 Ligase
CRBN ligand-76 is a ligand for the CRBN E3 ubiquitin ligase, facilitating the development of PROTAC (Proteolysis Targeting Chimeras). This compound engages specifically with the CRBN E3 ligase, promoting ubiquitination and degradation of target proteins. Its application in targeted protein degradation offers potential for therapeutic intervention in various diseases, including cancer and neurodegenerative disorders. -
Ligands for E3 Ligase
CRBN ligand-148 is an E3 ubiquitin ligase ligand specifically targeting cereblon (CRBN). This compound facilitates the development of proteolysis-targeting chimeras (PROTACs) by promoting the ubiquitination and subsequent degradation of target proteins. Its biological activity is leveraged in research focused on targeted protein degradation and the modulation of cellular pathways. -
Ligand for E3 Ligase
CRBN ligand-606 is a potent ligand for the E3 ubiquitin ligase cereblon (CRBN). This compound facilitates the recruitment of the CRBN protein, enabling targeted protein degradation through the formation of PROTACs when linked to specific target protein ligands. It is particularly useful in the study of protein homeostasis and degradation pathways, making it valuable for various research applications in cellular biology and therapeutic development. -
Ligand for E3 Ligase
CRBN ligand-298 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), enabling the selective recruitment of CRBN to target proteins. By facilitating the formation of a PROTAC (proteolysis-targeting chimera), CRBN ligand-298 functions to promote targeted protein degradation, making it a valuable tool for studies in protein regulation and therapeutic development. This reagent is essential for researchers investigating the therapeutic potential of targeted protein degradation pathways. -
Ligand for E3 Ligase
CRBN ligand-371 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be conjugated to a target protein ligand through a linker to create a proteolysis-targeting chimera (PROTAC). CRBN ligand-371 is useful in studies involving targeted protein degradation and the modulation of cellular pathways.
