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Form	MW
(S,R,R)-VH032 This page	430.56
(S,R,R)-VH032 hydrochloride	467.02

(S,R,R)-VH032

VHL Ligand

(S,R,R)-VH032 is a selective VHL ligand that facilitates targeted protein degradation through its interaction with the von Hippel-Lindau (VHL) E3 ubiquitin ligase complex. This compound serves as a crucial building block in the synthesis of PROTACs, specifically enabling the development of NCOA4 degrader-1. Its application in research highlights its potential for advancing studies in targeted protein degradation and therapeutic intervention strategies.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Ligand / Binder
CAS Number	2489876-59-5
Applications	VHL Ligand
Formula	C₂₂H₃₀N₄O₃S
Molecular Weight	430.56
SMILES	CC1=C(SC=N1)C(C=C2)=CC=C2CNC([C@H]3N(C[C@@H](C3)O)C([C@H](N)C(C)(C)C)=O)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.