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SJ1008066

Catalog No.: A80595
MAGE-A11 Inhibitor
SJ1008066 is an inhibitor of the MAGE-A11 protein, demonstrating an IC50 of 0.13 μM. It specifically binds to the MAGE homology domain (MHD), effectively disrupting the interaction between MAGE-A11 and PCF11. This mechanism presents valuable opportunities for research into cancer biology and therapeutic strategies targeting MAGE-A11 associated pathways.
SJ1008066 2758867-71-7 MAGE-A11 Inhibitor
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionSJ1008066 is an inhibitor of the MAGE-A11 protein, demonstrating an IC50 of 0.13 μM. It specifically binds to the MAGE homology domain (MHD), effectively disrupting the interaction between MAGE-A11 and PCF11. This mechanism presents valuable opportunities for research into cancer biology and therapeutic strategies targeting MAGE-A11 associated pathways.
Product Information
Catalog NumA80595
FormulaC21H22N4
Molecular Weight330.43
CAS Number2758867-71-7
SMILESC1(NCCCNCC2=CC3=C(NC=C3)C=C2)=C4C=CC=CC4=NC=C1
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PROTAC > E3 Ligase Ligands