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VHL Ligand 39

E3 Ligase Ligand

VHL Ligand 39 is a conjugate of the VHL E3 ligase, acting as a pivotal intermediate in the construction of PROTAC (proteolysis-targeting chimera) molecules. This compound facilitates targeted protein degradation by harnessing the ubiquitin-proteasome system, enabling researchers to modulate protein levels for various biological studies. Its applications extend to investigating cellular signaling pathways and therapeutic mechanisms involving targeted degradation of specific proteins.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Degrader
CAS Number	2876809-75-3
Applications	E3 Ligase Ligand
Formula	C₃₂H₄₅FN₄O₇S
Molecular Weight	648.79
SMILES	CC1=C(SC=N1)C2=CC=C(C(OCC(OCC)OCC)=C2)CNC([C@@H]3C[C@H](CN3C([C@H](C(C)(C)C)NC(C4(CC4)F)=O)=O)O)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.