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Pseudouridimycin TFA

RNAP Inhibitor

Pseudouridimycin TFA is a selective inhibitor of bacterial RNA polymerase (RNAP), demonstrating an IC50 of approximately 0.1 μM and minimum inhibitory concentrations (MICs) ranging from 4-6 μg/mL. This C-nucleoside analogue exhibits effective antibacterial activity against both Gram-negative and Gram-positive bacteria. In vitro studies confirm its capacity to inhibit bacterial growth, and it also shows efficacy in a mouse model of purulent streptococcal peritonitis, making it valuable for research in antibacterial mechanisms.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	2760807-99-4
Applications	RNAP Inhibitor
Formula	C₁₉H₂₇F₃N₈O₁₁
Molecular Weight	600.46
Synonyms	PUM TFA
SMILES	O=C1NC(C([C@H]2[C@@H]([C@@H]([C@@H](CNC([C@H](CCC(N)=O)N(C(CNC(N)=N)=O)O)=O)O2)O)O)=CN1)=O.OC(C(F)(F)F)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.