Fig. 1 · Structure
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PSF-IN-2
PSF Inhibitor
PSF-IN-2 is a potent PSF inhibitor with an IC50 of 0.005 pM. It demonstrates significant anti-cancer activity, effectively inhibiting the proliferation of 22Rv1 cells with an IC50 of 0.5 μM. By disrupting the interaction between PSF and RNA, PSF-IN-2 activates the p53 signaling pathway, leading to increased expression of pro-apoptotic genes, promotion of apoptosis, and cell cycle arrest. This compound is valuable for research in cancer biology and therapeutic development.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 185418-37-5 |
| Applications | PSF Inhibitor |
| Formula | C18H16O5 |
| Molecular Weight | 312.32 |
| SMILES | O=C1OC2=C(C(C3=CC=C(OC)C=C3)=C1)C=CC(OC)=C2OC |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.