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Pt(II)-NHC complex 2C

ICD Inducer

Pt(II)-NHC Complex 2C is a Platinum(II) complex featuring an N-heterocyclic carbene, which functions as an immunogenic cell death (ICD) inducer. This compound effectively induces endoplasmic reticulum stress (ERS) and generates reactive oxygen species (ROS) in liver cancer cells, leading to the release of damage-associated molecular patterns (DAMP). Additionally, Pt(II)-NHC Complex 2C inhibits cell cycle progression at the S phase and promotes significant apoptosis. Its demonstrated anti-liver cancer properties in mouse models and the activation of immune cells in liver injury contexts make it a valuable tool for cancer research and therapeutic investigations.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inducer
CAS Number	3035433-94-1
Applications	ICD Inducer
Formula	C₂₄H₂₃F₂I₂N₃Pt
Molecular Weight	840.35
Synonyms	Platinum(II)-N-heterocyclic carbene complex 2C
SMILES	I[Pt](I)([N]1=CC=CC=C1)=C(N2CC)N(CC)C(C3=CC=C(F)C=C3)=C2C4=CC=C(F)C=C4

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.