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PTP1B/TC-PTP IN-1

PTP1B and TC-PTP Inhibitor

PTP1B/TC-PTP IN-1 is a potent dual inhibitor of protein tyrosine phosphatase 1B (PTP1B) and T-cell protein tyrosine phosphatase (TC-PTP). This compound exhibits significant biological activity in the modulation of insulin signaling and immune response pathways. It serves as a valuable tool for research applications, including the development of PROTACs, such as DU-14, targeting PTP1B and TC-PTP for therapeutic interventions in metabolic and autoimmune disorders.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	3053414-48-2
Applications	PTP1B and TC-PTP Inhibitor
Formula	C₄₂H₄₆BrF₂N₄O₁₁P
Molecular Weight	931.71
SMILES	O=P(O)(O)C(F)(F)C(C=C1)=CC=C1C[C@H](NC([C@@H](NC(CC2=CC(OC)=C(C=C2)O)=O)CC3=CC=CC=C3)=O)C(N[C@@H](CCCCNC(C4=CC(Br)=C(C=C4)C)=O)C(O)=O)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.