Fig. 1 · Structure
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PTPN22-IN-1
PTPN22 Inhibitor
PTPN22-IN-1 is a selective inhibitor of the protein tyrosine phosphatase PTPN22, exhibiting an IC50 of 1.4 µM and a Ki of 0.50 µM. This compound demonstrates a >7-10 fold selectivity for PTPN22 over related phosphatases, indicating its potential for targeted applications. PTPN22-IN-1 enhances antitumor immune responses, making it a valuable tool for research in cancer immunotherapy and immune modulation studies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2580935-57-3 |
| Applications | PTPN22 Inhibitor |
| Formula | C26H21N3O5 |
| Molecular Weight | 455.46 |
| SMILES | O=C1C2=CC(NC([C@H](C)NC(C3=CC=C(C4=CC=CC=C4)C=C3)=O)=O)=CC=C2NC=C1C(O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.