Fig. 1 · Structure
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PTX80
p62 Antagonist
PTX80 is a potent antagonist of p62 with an IC50 value of 31.18 nM. This compound demonstrates significant anti-tumor activity by reducing tumor volume in HCT116 colorectal cancer mouse xenograft models. PTX80 is relevant for studying p62-related pathways and their implications in cancer research.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 2376297-69-5 |
| Applications | p62 Antagonist |
| Formula | C26H26N4O3S |
| Molecular Weight | 474.57 |
| SMILES | O=C(/C(CN(C/1)S(CCCN(C)C)(=O)=O)=C/C2=CC=C(C=C2)C#N)C1=C\C3=CC=C(C=C3)C#N |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.