Fig. 1 · Structure
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PU.1-IN-1
PU.1 Inhibitor
PU.1-IN-1 is a potent inhibitor of PU.1, demonstrating an IC50 of 2 nM. This compound effectively reduces rMANF-induced expression of miR-223, highlighting its role in modulating inflammatory responses. PU.1-IN-1 is primarily utilized in research focused on understanding the regulatory mechanisms of gene expression and inflammation, making it a valuable tool in immunology and related fields.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 873588-27-3 |
| Applications | PU.1 Inhibitor |
| Formula | C18H22N2O2S |
| Molecular Weight | 330.44 |
| SMILES | O=S(C1=CC=C(C2CCCCC2)C=C1)(NCC3=CC=NC=C3)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.