Fig. 1 · Structure
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PU-H39
Grp94 Inhibitor
PU-H39 is a selective Grp94 inhibitor with an IC50 of 0.12 μM. It demonstrates significant inhibitory effects on MKNK2 and ROCK2 kinases, achieving 34% and 32% inhibition at a concentration of 10 μM, respectively. This compound is relevant for research focused on breast cancer and its associated signaling pathways.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 852030-38-7 |
| Applications | Grp94 Inhibitor |
| Formula | C16H13Cl2N5S |
| Molecular Weight | 378.28 |
| SMILES | ClC1=CC=C(SC2=NC=3C(=NC=NC3N2CCCC#C)N)C(Cl)=C1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.