Fig. 1 · Structure
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PU-H54
Grp94 Inhibitor
PU-H54 is a selective inhibitor of Grp94, a member of the Hsp90 chaperone family implicated in cancer progression, particularly in breast cancer research. This compound features an alkyne group, enabling its application in click chemistry through copper-catalyzed azide-alkyne cycloaddition (CuAAc), facilitating the study of protein interactions. PU-H54 serves as a valuable tool for exploring the role of chaperone proteins in malignancy and developing potential therapeutic strategies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1454619-13-6 |
| Applications | Grp94 Inhibitor |
| Formula | C18H19N5S |
| Molecular Weight | 337.44 |
| SMILES | NC1=C2N=C(SC3=CC=C(C)C=C3C)N=C2N(CCCC#C)C=N1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.