Fig. 1 · Structure
Documents & Downloads
Purfalcamine
PfCDPK1 Inhibitor
Purfalcamine is a selective inhibitor of Plasmodium falciparum calcium-dependent protein kinase 1 (PfCDPK1), exhibiting an IC50 of 17 nM and an EC50 of 230 nM. It demonstrates potent antimalarial activity by inducing developmental arrest of malaria parasites at the schizont stage. This compound serves as a valuable tool for investigating the role of PfCDPK1 in malaria pathogenesis and development, offering insights into potential therapeutic strategies against malaria.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1038620-68-6 |
| Applications | PfCDPK1 Inhibitor |
| Formula | C29H33FN8O |
| Molecular Weight | 528.62 |
| SMILES | O=C(C1=CC=C(NC2=C3N=CN(C4=CC=CC(F)=C4)C3=NC(N[C@H]5CC[C@H](N)CC5)=N2)C=C1)N6CCCCC6 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.