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Purine phosphoribosyltransferase-IN-1

6-oxopurine PRT Inhibitor

Purine phosphoribosyltransferase-IN-1 is a selective inhibitor of 6-oxopurine purine phosphoribosyltransferases in Plasmodium falciparum, P. vivax, and Trypanosoma brucei, exhibiting Ki values of 50 nM, 20 nM, and 2 nM, respectively. This compound effectively disrupts nucleotide synthesis pathways, providing a valuable tool for research in parasitic diseases. Its potent activity makes it suitable for studies focused on malaria and trypanosomiasis, aiding in the development of novel therapeutic strategies.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	2784631-28-1
Applications	6-oxopurine PRT Inhibitor
Formula	C₁₁H₁₅N₅Na₄O₁₀P₂
Molecular Weight	531.17
SMILES	O=P(O[Na])(O[Na])COC[C@@H](OC[C@@H](P(O[Na])(O[Na])=O)O)CN1C=NC2=C1N=C(N)NC2=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.