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Purine riboside-5'-O-triphosphate sodium

Nebularine metabolite

Purine riboside-5'-O-triphosphate sodium is a potent metabolite of Nebularine that primarily targets DNA primase, inhibiting ATP and GTP polymerization activities with IC50 values of 35 µM and 28 µM, respectively, in human enzymes. Additionally, this compound exhibits inhibitory activity against calmodulin-dependent protein kinase II (CaMKII) with a Ki value of 590 µM. Its biological activities make it valuable for research focused on DNA replication and kinase signaling pathways.

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Specifications

Manufacturer	Adooq Bioscience
CAS Number	35892-95-6
Applications	Nebularine metabolite
Formula	C₁₀H₁₁N₄Na₄O₁₃P₃
Molecular Weight	580.09
Synonyms	PTP tetrasodium
SMILES	O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP(OP(OP(O[Na])(O[Na])=O)(O[Na])=O)(O[Na])=O)N2C3=NC=NC=C3N=C2

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.