Fig. 1 · Structure
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Purine riboside triphosphate
Triphosphate Derivative
Purine riboside triphosphate is a triphosphate derivative that serves as an active metabolite in various biochemical pathways. This compound effectively inhibits DNA primase and exhibits significant activity against both ATP and GTP polymerization with IC50 values of 35 µM and 28 µM, respectively, for human DNA primase. Additionally, Purine riboside triphosphate inhibits calmodulin-dependent protein kinase II (CaMKII) with a Ki value of 590 µM. Its applications are relevant in studies of nucleic acid synthesis and kinase signaling pathways.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 23197-96-8 |
| Applications | Triphosphate Derivative |
| Formula | C10H15N4O13P3 |
| Molecular Weight | 492.17 |
| Synonyms | PTP |
| SMILES | O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP(OP(OP(O)(O)=O)(O)=O)(O)=O)N2C3=NC=NC=C3N=C2 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.