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Purvalanol A

Purvalanol A

Name: Purvalanol A
Brand: Adooq Bioscience
SKU: A15517
Rating: 100 (268 reviews)

Catalog No.: A15517

CDK inhibitor

Purvalanol A Chemical Structure

CAS NO. 212844-53-6

Purvalanol A is a potent, cell-permeable cyclin-dependent protein kinase (cdk) inhibitor. IC50 values are 4, 70, 35, 850 and 75 nM for cdc2/cyclin B, cdk2/cyclin A, cdk2/cyclin E, cdk4/cyclin D1 and cdk5-p35 respectively.

Availability: In stock

Package	Price	Qty
10 mg	$45.00
25 mg	$90.00
50 mg	$135.00
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Biological Activity

Targets

Cdc2/CyclinB	CDK2/CyclinE	CDK2/CyclinA	CDK4/CyclinD1
4 nM	35 nM	70 nM	850 nM

Solubility *

In vitro	DMSO	Warmed: 53 mg/mL (136.28 mM)
	Water	Insoluble
	Ethanol	Warmed: 11 mg/mL (28.28 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	25.71 mL	128.57 mL	257.14 mL
0.5 mM	5.14 mL	25.71 mL	51.43 mL
1 mM	2.57 mL	12.86 mL	25.71 mL
5 mM	0.51 mL	2.57 mL	5.14 mL

*The above data is based on the productmolecular weight 388.89. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Chemical Properties

Catalog Num	A15517
Actions	Inhibitor
CAS No.	212844-53-6
Formula	C19H25ClN6O
M. Wt	388.89
Purity	>98%
Synonyms	NG-60
SMILES	CC(C)N1C2=NC(N[[email protected]](C(C)C)CO)=NC(NC3=CC(Cl)=CC=C3)=C2N=C1
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.