Purvalanol A

Catalog No.: A15517

CDK inhibitor

Purvalanol A Chemical Structure

CAS NO. 212844-53-6

Purvalanol A is a potent, cell-permeable cyclin-dependent protein kinase (cdk) inhibitor. IC50 values are 4, 70, 35, 850 and 75 nM for cdc2/cyclin B, cdk2/cyclin A, cdk2/cyclin E, cdk4/cyclin D1 and cdk5-p35 respectively.

Availability: In stock

Package Price Qty
10 mg

Regular Price: $75.00

Special Price $60.00

25 mg

Regular Price: $120.00

Special Price $96.00

50 mg

Regular Price: $175.00

Special Price $140.00

Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

Purvalanol A is a potent, cell-permeable cyclin-dependent protein kinase (cdk) inhibitor. IC50 values are 4, 70, 35, 850 and 75 nM for cdc2/cyclin B, cdk2/cyclin A, cdk2/cyclin E, cdk4/cyclin D1 and cdk5-p35 respectively.
Targets
Cdc2/CyclinB CDK2/CyclinE CDK2/CyclinA CDK4/CyclinD1
4 nM35 nM70 nM850 nM
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 25.71 mL 128.57 mL 257.14 mL
0.5 mM 5.14 mL 25.71 mL 51.43 mL
1 mM 2.57 mL 12.86 mL 25.71 mL
5 mM 0.51 mL 2.57 mL 5.14 mL

*The above data is based on the productmolecular weight 388.89. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A15517
Actions Inhibitor
M. Wt 388.89
Formula C19H25ClN6O
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 212844-53-6
Synonyms NG-60
SMILES CC(C)N1C2=NC(N[[email protected]](C(C)C)CO)=NC(NC3=CC(Cl)=CC=C3)=C2N=C1

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