Purvalanol A

Catalog No.: A15517

CDK inhibitor

Purvalanol A

Purvalanol A Chemical Structure

CAS NO. 212844-53-6

Purvalanol A is a potent, cell-permeable cyclin-dependent protein kinase (cdk) inhibitor. IC50 values are 4, 70, 35, 850 and 75 nM for cdc2/cyclin B, cdk2/cyclin A, cdk2/cyclin E, cdk4/cyclin D1 and cdk5-p35 respectively.

Availability: In stock

Package Price Qty
10 mg
$45.00
25 mg
$90.00
50 mg
$135.00
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Biological Activity

Purvalanol A is a potent, cell-permeable cyclin-dependent protein kinase (cdk) inhibitor. IC50 values are 4, 70, 35, 850 and 75 nM for cdc2/cyclin B, cdk2/cyclin A, cdk2/cyclin E, cdk4/cyclin D1 and cdk5-p35 respectively.
Targets
Cdc2/CyclinB CDK2/CyclinE CDK2/CyclinA CDK4/CyclinD1
4 nM35 nM70 nM850 nM
In vitro DMSO Warmed: 53 mg/mL (136.28 mM)
Water Insoluble
Ethanol Warmed: 11 mg/mL (28.28 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 25.71 mL 128.57 mL 257.14 mL
0.5 mM 5.14 mL 25.71 mL 51.43 mL
1 mM 2.57 mL 12.86 mL 25.71 mL
5 mM 0.51 mL 2.57 mL 5.14 mL

*The above data is based on the productmolecular weight 388.89. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A15517
Actions Inhibitor
CAS No. 212844-53-6
Formula C19H25ClN6O
M. Wt 388.89
Purity >98%
Synonyms NG-60
SMILES CC(C)N1C2=NC(N[[email protected]](C(C)C)CO)=NC(NC3=CC(Cl)=CC=C3)=C2N=C1
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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