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Purvalanol A is a potent, cell-permeable cyclin-dependent protein kinase (cdk) inhibitor. IC50 values are 4, 70, 35, 850 and 75 nM for cdc2/cyclin B, cdk2/cyclin A, cdk2/cyclin E, cdk4/cyclin D1 and cdk5-p35 respectively.
Targets
| Cdc2/CyclinB | CDK2/CyclinE | CDK2/CyclinA | CDK4/CyclinD1 | |
| 4 nM | 35 nM | 70 nM | 850 nM |
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 25.71 mL | 128.57 mL | 257.14 mL |
| 0.5 mM | 5.14 mL | 25.71 mL | 51.43 mL |
| 1 mM | 2.57 mL | 12.86 mL | 25.71 mL |
| 5 mM | 0.51 mL | 2.57 mL | 5.14 mL |
*The above data is based on the productmolecular weight 388.89. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A15517 |
|---|---|
| Actions | Inhibitor |
| M. Wt | 388.89 |
| Formula | C19H25ClN6O |
| Solubility | DMSO |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 212844-53-6 |
| Synonyms | NG-60 |
| SMILES | CC(C)N1C2=NC(N[[email protected]](C(C)C)CO)=NC(NC3=CC(Cl)=CC=C3)=C2N=C1 |
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