PX 12

Catalog No.: A13831

Trx-1 inhibitor

PX 12

PX 12 Chemical Structure

CAS NO. 141400-58-0

PX 12 inhibits hypoxia-induced HIF-1a transcriptional activity (IC50 11 nM) and proliferation of HT29 and MCF-7 tumor cells (IC50 1.9 and 0.9 uM, respectively).

Availability: In stock

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10 mg
$85.00
25 mg
$160.00
50 mg
$300.00
100 mg
$500.00
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Biological Activity

PX 12 inhibits hypoxia-induced HIF-1a transcriptional activity (IC50 11 nM) and proliferation of HT29 and MCF-7 tumor cells (IC50 1.9 and 0.9 uM, respectively).
Targets
Trx-1
In vitro (25°C) DMSO 37 mg/mL (196.48 mM)
Water Insoluble
Ethanol 37 mg/mL
In vivo 2% DMSO+30% PEG 300+ddH2O 10 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 53.1 mL 265.52 mL 531.04 mL
0.5 mM 10.62 mL 53.1 mL 106.21 mL
1 mM 5.31 mL 26.55 mL 53.1 mL
5 mM 1.06 mL 5.31 mL 10.62 mL

*The above data is based on the productmolecular weight 188.31. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A13831
Actions Inhibitor
CAS No. 141400-58-0
Formula C7H12N2S2
M. Wt 188.31
Purity >98%
Synonyms IV-2, PX-12, PX12
SMILES CCC(C)SSC1=NC=CN1
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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