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Publications citing Adooq Products
Chemical Information
| Catalog Num | A14319 |
|---|---|
| Actions | Inhibitor |
| M. Wt | 394.12 |
| Formula | C13H20Cl4N2O3 |
| Solubility | DMSO |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 685898-44-6 |
| Synonyms | 0 |
| SMILES | C1=CC(=CC=C1C[[email protected]@H](C(=O)O)N)[N+](CCCl)(CCCl)[O-].Cl.Cl |
Description |
PX-478 is HIF-1alpha inhibitor, is also an orally active small molecule with potential antineoplastic activity. PX-478 has excellent activity against established human tumor xenografts, providing tumor regressions with prolonged growth delays which correlate positively with HIF-1 levels. PX-478 is a highly water soluble molecule, with good i.v., i.p. and p.o. antitumor activity. | ||||||||||
Targets |
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| Solubility (25°C)* | In vitro | DMSO | 78 mg/mL (197.9 mM) |
|---|---|---|---|
| Water | 78 mg/mL (197.9 mM) | ||
| Ethanol | 78 mg/mL (197.9 mM) | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 25.37 mL | 126.86 mL | 253.73mL |
| 0.5 mM | 5.07 mL | 25.37 mL | 50.75 mL |
| 1 mM | 2.54 mL | 12.69 mL | 25.37 mL |
| 5 mM | 0.51 mL | 2.54 mL | 5.07 mL |
*The above data is based on the productmolecular weight 394.12. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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