PX-478 HCl

Catalog No.: A14319

HIF-1alpha inhibitor

PX-478 HCl

PX-478 HCl Chemical Structure

CAS NO. 685898-44-6

PX-478 is HIF-1alpha inhibitor, is also an orally active small molecule with potential antineoplastic activity. PX-478 has excellent activity against established human tumor xenografts, providing tumor regressions with prolonged growth delays which correlate positively with HIF-1 levels. PX-478 is a highly water soluble molecule, with good i.v., i.p. and p.o. antitumor activity.

Availability: In stock

Package Price Qty
10 mg
$140.00
25 mg
$250.00
50 mg
$350.00
10mM * 1mL in DMSO
$85.00
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Biological Activity

PX-478 is HIF-1alpha inhibitor, is also an orally active small molecule with potential antineoplastic activity. PX-478 has excellent activity against established human tumor xenografts, providing tumor regressions with prolonged growth delays which correlate positively with HIF-1 levels. PX-478 is a highly water soluble molecule, with good i.v., i.p. and p.o. antitumor activity.
Targets
HIF-1α
In vitro DMSO 73 mg/mL (185.21 mM)
Water 73 mg/mL (185.21 mM)
Ethanol 73 mg/mL (185.21 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 25.37 mL 126.86 mL 253.73 mL
0.5 mM 5.07 mL 25.37 mL 50.75 mL
1 mM 2.54 mL 12.69 mL 25.37 mL
5 mM 0.51 mL 2.54 mL 5.07 mL

*The above data is based on the productmolecular weight 394.12. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A14319
Actions Inhibitor
CAS No. 685898-44-6
Formula C13H20Cl4N2O3
M. Wt 394.12
Purity >98%
Synonyms 0
SMILES C1=CC(=CC=C1C[[email protected]@H](C(=O)O)N)[N+](CCCl)(CCCl)[O-].Cl.Cl
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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