PX-478 HCl

Catalog No.: A14319
HIF-1alpha inhibitor
PX-478 is HIF-1alpha inhibitor, is also an orally active small molecule with potential antineoplastic activity. PX-478 has excellent activity against established human tumor xenografts, providing tumor regressions with prolonged growth delays which correlate positively with HIF-1 levels. PX-478 is a highly water soluble molecule, with good i.v., i.p. and p.o. antitumor activity.
Grouped product items
Size Price Stock Qty
2mg
$40.00
In stock
5mg
$75.00
In stock
10mg
$130.00
In stock
25mg
$210.00
In stock
50mg
$285.00
In stock
100mg
$450.00
In stock
10mM * 1mL in DMSO
$75.00
In stock
Bulk Size
Bulk Discount
Free Delivery on orders over $500

Important Notice: For research use only. We do not sell to patients.

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Biological Activity
Discription PX-478 is HIF-1alpha inhibitor, is also an orally active small molecule with potential antineoplastic activity. PX-478 has excellent activity against established human tumor xenografts, providing tumor regressions with prolonged growth delays which correlate positively with HIF-1 levels. PX-478 is a highly water soluble molecule, with good i.v., i.p. and p.o. antitumor activity.
Targets
Target Value
Cell Research
Cell Line Type Value Description References
Product Information
Catalog Num A14319
Formula C13H20Cl4N2O3
Molecular Weight 394.12
CAS Number 685898-44-6
SMILES C1=CC(=CC=C1C[C@@H](C(=O)O)N)[N+](CCCl)(CCCl)[O-].Cl.Cl
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 1 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Solubility
In vitro DMSO 73 mg/mL (185.21 mM)
Water 73 mg/mL (185.21 mM)
Ethanol 73 mg/mL (185.21 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Preparing Stock Solutions
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 25.37 mL 126.86 mL 253.73 mL
0.5 mM 5.07 mL 25.37 mL 50.75 mL
1 mM 2.54 mL 12.69 mL 25.37 mL
5 mM 0.51 mL 2.54 mL 5.07 mL
Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C1V1 = C2V2

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