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Pyrazinoylguanidine

Antihypertensive Agent

Pyrazinoylguanidine (PZG) is an antihypertensive agent known for its ability to lower both systolic and diastolic blood pressure in patients with primary hypertension. It functions by inhibiting the reabsorption of urea in renal tubules, leading to increased clearance and reduced serum urea levels. Additionally, PZG demonstrates beneficial effects on metabolic parameters in type 2 diabetes, including the reduction of hyperglycemia, hyperinsulinemia, triglycerides, cholesterol, and free fatty acids. Its mechanism does not interfere with the serum concentrations of vital electrolytes such as sodium, potassium, and chloride, making it a valuable tool in hypertension and metabolic research.

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Specifications

Manufacturer	Adooq Bioscience
CAS Number	60398-24-5
Applications	Antihypertensive Agent
Formula	C₆H₇N₅O
Molecular Weight	165.15
Synonyms	PZG
SMILES	N=C(N)NC(C1=CN=CC=N1)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.