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Pyripyropene B

ACAT Inhibitor

Pyripyropene B is a potent inhibitor of acyl-CoA: cholesterol acyltransferase 2 (ACAT2), derived from the fungus Aspergillus fumigatus FO 1289. This compound exhibits significant inhibitory activity with an IC50 value of 117 nM, making it a valuable tool for studying cholesterol metabolism. Pyripyropene B is utilized in research applications focused on lipid regulation and related metabolic disorders.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	151519-44-7
Applications	ACAT Inhibitor
Formula	C₃₂H₃₉NO₁₀
Molecular Weight	597.65
SMILES	C[C@@]12[C@]3([H])[C@@]([C@H](C[C@@]1([H])[C@@](C)([C@H](CC2)OC(C)=O)COC(CC)=O)OC(C)=O)(OC4=C(C(OC(C5=CN=CC=C5)=C4)=O)[C@@H]3O)C

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.