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Biological Activity
Pyrotinib dimaleate (SHR-1258 dimaleate) is a potent and selective EGFR/HER2 dual inhibitor with IC50 s of 13 and 38 nM, respectively.
| In vitro | DMSO | Insoluble | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 12.27 mL | 61.33 mL | 122.67 mL |
| 0.5 mM | 2.45 mL | 12.27 mL | 24.53 mL |
| 1 mM | 1.23 mL | 6.13 mL | 12.27 mL |
| 5 mM | 0.25 mL | 1.23 mL | 2.45 mL |
*The above data is based on the productmolecular weight 815.22. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A21756 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 1397922-61-0 |
| Formula | C40H39ClN6O11 |
| M. Wt | 815.22 |
| Purity | >98% |
| Synonyms | SHR-1258 dimaleate, SHR1258, SHR 1258 |
| SMILES | O=C(NC1=C(OCC)C=C2N=CC(C#N)=C(NC3=CC=C(OCC4=NC=CC=C4)C(Cl)=C3)C2=C1)/C=C/[[email protected]@H]5N(C)CCC5.O=C(O)/C=C\C(O)=O.O=C(O)/C=C\C(O)=O |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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