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Pyruvate carboxylase

Mitochondrial Anaplerotic Enzyme

Pyruvate carboxylase is a critical mitochondrial anaplerotic enzyme that catalyzes the conversion of pyruvate to oxaloacetate. This enzyme plays a vital role in maintaining the activity of the tricarboxylic acid cycle and redox balance, while also facilitating gluconeogenesis and fatty acid synthesis in the liver. In addition, pyruvate carboxylase expression is significantly elevated in early-stage non-small cell lung cancer (NSCLC), contributing to tumor proliferation through enhanced nucleotide and lipid synthesis. Research applications include investigations in prediabetes type 2 and NSCLC, where the enzyme's activity is linked to metabolic dysregulation.

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Specifications

Manufacturer	Adooq Bioscience
CAS Number	9014-19-1
Applications	Mitochondrial Anaplerotic Enzyme

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.