PZ-128 is a specific and reversible antagonist of protease-activated receptor-1 (PAR1), functioning as a cell-penetrating lipopeptide pepducin. By targeting the cytoplasmic surface of PAR1, PZ-128 effectively interrupts signaling to internally-located G proteins. This compound exhibits significant biological activities, including antiplatelet, anti-metastatic, anti-angiogenic, and anticancer effects, making it beneficial for research applications in cardiovascular and cancer biology.
PZ-128 is a specific and reversible antagonist of protease-activated receptor-1 (PAR1), functioning as a cell-penetrating lipopeptide pepducin. By targeting the cytoplasmic surface of PAR1, PZ-128 effectively interrupts signaling to internally-located G proteins. This compound exhibits significant biological activities, including antiplatelet, anti-metastatic, anti-angiogenic, and anticancer effects, making it beneficial for research applications in cardiovascular and cancer biology.
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