PZ-1922 free base is a centrally-active antagonist of the 5-HT6 receptor and the 5-HT3 receptor, exhibiting binding affinities of Ki values of 17 nM and 0.45 nM, respectively. This compound also reversibly inhibits monoamine oxidase B, with a pIC50 of 8.93. PZ-1922 free base has demonstrated efficacy in reversing memory deficits induced by Scopolamine in novel object recognition tests in rats, as well as preventing beta-amyloid-induced cognitive decline in T-maze assessments. These properties make it a valuable tool for investigating neuropharmacology and disorders related to memory impairment.
PZ-1922 free base is a centrally-active antagonist of the 5-HT6 receptor and the 5-HT3 receptor, exhibiting binding affinities of Ki values of 17 nM and 0.45 nM, respectively. This compound also reversibly inhibits monoamine oxidase B, with a pIC50 of 8.93. PZ-1922 free base has demonstrated efficacy in reversing memory deficits induced by Scopolamine in novel object recognition tests in rats, as well as preventing beta-amyloid-induced cognitive decline in T-maze assessments. These properties make it a valuable tool for investigating neuropharmacology and disorders related to memory impairment.
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