Fig. 1 · Structure
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QAQ
Light-Controlled Open Channel Blocker
QAQ is a light-controlled open channel blocker that selectively inhibits voltage-gated sodium (Nav) and potassium (Kv) channels in its trans form, while remaining inactive in the cis form. This compound is membrane-impermeant, allowing it to penetrate only pain-sensing neurons that express endogenous import channels. QAQ serves as a light-sensitive analgesic, making it a valuable tool for investigating signaling mechanisms in both acute and chronic pain research.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Blocker |
| CAS Number | 1204416-85-2 |
| Applications | Light-Controlled Open Channel Blocker |
| Formula | C28H44N6O22+ |
| Molecular Weight | 496.69 |
| SMILES | O=C(NC1=CC=C(/N=N/C2=CC=C(NC(C[N+](CC)(CC)CC)=O)C=C2)C=C1)C[N+](CC)(CC)CC |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.