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QGC583

APA Inhibitor

QGC583 is a selective inhibitor of Aminopeptidase A (APA), demonstrating robust oral bioavailability and the ability to penetrate the blood-brain barrier, with an IC50 of 4 nM. This compound effectively inhibits APA activity in various tissues, including the brain, kidneys, and heart, making it valuable for research applications that investigate the physiological roles of APA and its therapeutic potential in cardiovascular and neurological conditions.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	2417001-25-1
Applications	APA Inhibitor
Formula	C₁₃H₂₀NO₅P
Molecular Weight	301.28
SMILES	O=P([C@@H](N)CCC(O)=O)(O)CCC1=C(OC)C=CC=C1

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.