Fig. 1 · Structure
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QM31
Apaf-1 Inhibitor
QM31 is a selective inhibitor of Apaf-1, blocking the formation of the apoptosome, a crucial complex for caspase activation. With an IC50 of 7.9 μM, QM31 demonstrates significant cytoprotective properties and enhances mitochondrioprotection. This compound is of particular interest in research focused on apoptosis regulation and the cellular response to DNA damage during the S-phase of the cell cycle.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 937735-00-7 |
| Applications | Apaf-1 Inhibitor |
| Formula | C39H38Cl4N4O4 |
| Molecular Weight | 768.56 |
| Synonyms | SVT016426 |
| SMILES | O=C(C(C1)N(CCC(C2=CC=CC=C2)C3=CC=CC=C3)C(CN(CCC4=CC=C(Cl)C=C4Cl)C1=O)=O)N(CC(N)=O)CCC5=CC=C(Cl)C=C5Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.