Fig. 1 · Structure
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QM385
SPR Inhibitor
QM385 is a highly selective sepiapterin reductase (SPR) inhibitor, exhibiting an IC50 of 1.49 nM. This compound effectively inhibits T-cell proliferation and mitigates autoimmunity at nanomolar concentrations. Owing to its favorable oral bioavailability, QM385 serves as a valuable tool for investigating the role of SPR in immune responses and potential therapeutic applications in autoimmune disorders.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2093421-02-2 |
| Applications | SPR Inhibitor |
| Formula | C17H18F3N7O2 |
| Molecular Weight | 409.37 |
| SMILES | O=C1NC(N2N=CC(C(N3CCN(CC(F)(F)F)CC3)=O)=C2C)=NN4C1=CC=C4 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.