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QND8

α7 nAChR Inhibitor

QND8 is a selective and potent inhibitor of the α7 nicotinic acetylcholine receptor (nAChR). It demonstrates significant biological activity by alleviating thermal and mechanical hyperalgesia in carrageenan-induced inflammatory pain models. QND8 effectively reduces swelling, inhibits the release of pro-inflammatory cytokines, and prevents leukocyte infiltration at the inflammatory site. This compound is valuable for research applications focused on inflammation and neurological disorders, including arthritis.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	1778682-60-2
Applications	α7 nAChR Inhibitor
Formula	C₁₅H₁₈N₄O
Molecular Weight	270.33
SMILES	OC1=CC=C(C2=CN(C3[C@H]4CC[N@](CC4)C3)N=N2)C=C1

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.