Fig. 1 · Structure
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Questiomycin A
GRP78 Degrader
Questiomycin A is a potent GRP78 degrader, targeting the cytoprotective endoplasmic reticulum chaperone to promote enhanced anticancer activity, particularly in conjunction with Sorafenib. Additionally, Questiomycin A exhibits antimicrobial properties and is derived from the metabolite of Pseudomonas chlororaphis HT66. This compound is valuable for research in the biological control of both cancer and plant diseases, providing insights into therapeutic strategies and molecular mechanisms.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Degrader |
| CAS Number | 1916-59-2 |
| Applications | GRP78 Degrader |
| Formula | C12H8N2O2 |
| Molecular Weight | 212.20 |
| Synonyms | Phx-3 |
| SMILES | O=C1C(N)=CC2=NC3=C(C=CC=C3)OC2=C1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.