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Fig. 1 · Structure
Cat. No.
A15216
CAS No.
111974-69-7
Formula
C21H25N3O2S
Mol. Weight
383.51

Documents & Downloads

Quetiapine

Cat. No. A15216 CAS 111974-69-7
Quetiapine is an atypical antipsychotic used in the treatment of schizophrenia, bipolar I mania, bipolar II depression, bipolar I depression.

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Biological Activity

Target & Activity

Target Activity Value
5-HT1A Receptor pKi 5.74
5-HT2A Receptor pKi 7.54
5-HT2C Receptor pKi 5.55
D2 Receptor pKi 7.25
5-HT1A Receptor pEC50 4.77
D2 Receptor pIC50 6.33

6 targets · Scroll to view more

Cellular Effect

Cell Line Activity Value Description Reference
HEK293 IC50 16900 nM Inhibition of sodium current measured using whole-cell patch clamp experiments in HEK-293 cells stably transfected with hNaV1.5 cDNA [PMID: 21300721]
Ventricular myocyte IC50 10.4 μM Inhibition of L-type calcium channel measured using whole-cell patch clamp in guinea pig ventricular myocytes [PMID: 22761000]
Ventricular myocyte IC50 10400 nM Inhibition of calcium current (ICaL) measured using whole-cell patch clamp experiments in isolated guinea pig ventricular myocytes [PMID: 21300721]

Specifications

Manufacturer Adooq Bioscience
CAS Number 111974-69-7
Formula C21H25N3O2S
Molecular Weight 383.51
Synonyms Ketipinor
SMILES
C1CN(CCN1CCOCCO)C2=NC3=CC=CC=C3SC4=CC=CC=C42

Storage & Solubility

In Vitro Solubility

Reported Solubility

SolventReported Solubility
DMSO 72 mg/mL (187.73 mM)
Ethanol <1 mg/mL

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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