Fig. 1 · Structure
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Queuine
TGT Substrate
Queuine is a selective substrate for tRNA guanine transglycosylase (TGT), facilitating the incorporation into eukaryotic tRNA. This modification influences mitochondrial function and the Warburg metabolic phenotype. A deficiency in Queuine can enhance aerobic glycolysis while inhibiting oxidative phosphorylation, which contributes to increased ammonia and lactate production, as well as elevated lactate dehydrogenase activity. Queuine is relevant in research applications related to autoimmune diseases, such as experimental models of multiple sclerosis, and cancer metabolic regulation, with its deficiency linked to reduced tRNA modification in tumor cells.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Substrate |
| CAS Number | 72496-59-4 |
| Applications | TGT Substrate |
| Formula | C12H15N5O3 |
| Molecular Weight | 277.28 |
| SMILES | O[C@@H]([C@H](C=C1)O)[C@H]1NCC2=CNC(NC(N)=N3)=C2C3=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.