Quipazine dimaleate is a potent 5-HT agonist, demonstrating a Ki value of 1.4 nM for displacing [3H]GR65630 from the 5-HT3 receptor in rat models. This compound exhibits antiviral activity against SARS-CoV-2, with an EC50 of 31.64 μM, and acts as a 5-HT3 receptor antagonist in peripheral models. Quipazine dimaleate is valuable for research in neurological diseases, providing insights into serotonin receptor modulation and antiviral mechanisms.
Quipazine dimaleate is a potent 5-HT agonist, demonstrating a Ki value of 1.4 nM for displacing [3H]GR65630 from the 5-HT3 receptor in rat models. This compound exhibits antiviral activity against SARS-CoV-2, with an EC50 of 31.64 μM, and acts as a 5-HT3 receptor antagonist in peripheral models. Quipazine dimaleate is valuable for research in neurological diseases, providing insights into serotonin receptor modulation and antiviral mechanisms.
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