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(R)-C12-200

Cationic Lipid

(R)-C12-200 is an ionizable cationic lipid that serves as a helper lipid in mRNA delivery applications. It has demonstrated effective functional mRNA delivery to head and neck squamous cell carcinoma xenograft tumor cells in NU/J immunocompromised mouse models, exhibiting minimal off-target effects on the liver and spleen. (R)-C12-200 is suitable for the formulation of lipid nanoparticles, making it a valuable tool in therapeutic mRNA studies.

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Specifications

Manufacturer	Adooq Bioscience
CAS Number	1226777-45-2
Applications	Cationic Lipid
Formula	C₇₀H₁₄₅N₅O₅
Molecular Weight	1136.93
SMILES	CCCCCCCCCC[C@@H](O)CN(C[C@H](O)CCCCCCCCCC)CCN(C[C@H](O)CCCCCCCCCC)CCN1CCN(CC1)CCN(C[C@H](O)CCCCCCCCCC)C[C@H](O)CCCCCCCCCC

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.