R-(+)-EU-1180-453

Catalog No.: A67241
NMDA Receptors Positive Modulator
R-(+)-EU-1180-453 is a positive allosteric modulator that targets NMDA receptors containing GluN2C and GluN2D subunits, demonstrating a pEC50 value of 5.5 for both rat receptor subtypes. This compound enhances the potency of glutamate, amplifying receptor responses to agonists while acting selectively on receptors co-bound with both necessary co-agonists. R-(+)-EU-1180-453 is suitable for research into neurological conditions, including Alzheimer's disease, Parkinson's disease, epilepsy, and neuropathic pain.
Grouped product items
Size Price Stock Qty
1mg
$330.00
In stock
5mg
$805.00
In stock
10mg
$1,110.00
In stock
25mg
$1,655.00
In stock
Bulk Size
Bulk Discount
Free Delivery on orders over $500
Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionR-(+)-EU-1180-453 is a positive allosteric modulator that targets NMDA receptors containing GluN2C and GluN2D subunits, demonstrating a pEC50 value of 5.5 for both rat receptor subtypes. This compound enhances the potency of glutamate, amplifying receptor responses to agonists while acting selectively on receptors co-bound with both necessary co-agonists. R-(+)-EU-1180-453 is suitable for research into neurological conditions, including Alzheimer's disease, Parkinson's disease, epilepsy, and neuropathic pain.
Product Information
Catalog NumA67241
FormulaC22H21FN2O3
Molecular Weight380.42
CAS Number2488764-06-1
SMILESC(OC1=CC=C(OC)C=C1)[C@H]2C=3N(CC(=O)N2CC4=CC(F)=CC=C4)C=CC3
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